INT298285

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Context Info
Confidence 0.50
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 0.56
Pain Relevance 0.32

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (Pou4f1, Runx3) DNA binding (Pou4f1, Runx3) cytoplasm (Runx3)
Pou4f1 (Mus musculus)
Runx3 (Mus musculus)
Pain Link Frequency Relevance Heat
Neurotransmitter 2 92.84 High High
trigeminal ganglion 150 89.16 High High
calcitonin gene related peptide 22 82.40 Quite High
substance P 6 64.64 Quite High
nociceptor 64 5.00 Very Low Very Low Very Low
Neuropeptide 8 5.00 Very Low Very Low Very Low
mu opioid receptor 8 5.00 Very Low Very Low Very Low
Somatostatin 6 5.00 Very Low Very Low Very Low
Central nervous system 4 5.00 Very Low Very Low Very Low
Spinal cord 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Targeted Disruption 86 89.88 High High
Ganglion Cysts 170 89.16 High High
Repression 14 5.00 Very Low Very Low Very Low
Pain 6 5.00 Very Low Very Low Very Low
Nociception 6 5.00 Very Low Very Low Very Low
Neurodegenerative Disease 6 5.00 Very Low Very Low Very Low
Death 4 5.00 Very Low Very Low Very Low
Herpes Simplex Virus 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Brn3a activation of the Runx3 gene appears to be mediated through direct binding to conserved upstream regulatory elements, constituting the first verified direct transactivator function for this factor.


Brn3a Positive_regulation (activation) of Runx3
1) Confidence 0.50 Published 2010 Journal Neural Dev Section Body Doc Link PMC2829025 Disease Relevance 0.49 Pain Relevance 0.32
It is highly likely that other signals and transcription factors are necessary to confer specificity on Runx3 activation by Brn3a.
Brn3a Positive_regulation (activation) of Runx3
2) Confidence 0.50 Published 2010 Journal Neural Dev Section Body Doc Link PMC2829025 Disease Relevance 0.07 Pain Relevance 0

General Comments

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