INT298289

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Context Info
Confidence 0.60
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 1.09
Pain Relevance 0.87

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (Ntrk2) cytosol (Ntrk2) plasma membrane (Ntrk2)
nucleus (Runx1) DNA binding (Runx1) kinase activity (Ntrk2)
Anatomy Link Frequency
nociceptors 1
neural 1
Runx1 (Mus musculus)
Ntrk2 (Mus musculus)
Pain Link Frequency Relevance Heat
nociceptor 64 97.68 Very High Very High Very High
trigeminal ganglion 150 95.68 Very High Very High Very High
calcitonin gene related peptide 22 52.32 Quite High
Neuropeptide 8 5.00 Very Low Very Low Very Low
mu opioid receptor 8 5.00 Very Low Very Low Very Low
substance P 6 5.00 Very Low Very Low Very Low
Somatostatin 6 5.00 Very Low Very Low Very Low
Central nervous system 4 5.00 Very Low Very Low Very Low
Spinal cord 4 5.00 Very Low Very Low Very Low
Serotonin 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Ganglion Cysts 170 95.68 Very High Very High Very High
Targeted Disruption 86 86.88 High High
Repression 14 73.88 Quite High
Pain 6 5.00 Very Low Very Low Very Low
Nociception 6 5.00 Very Low Very Low Very Low
Neurodegenerative Disease 6 5.00 Very Low Very Low Very Low
Death 4 5.00 Very Low Very Low Very Low
Herpes Simplex Virus 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Thus, it is likely that both Runx1 and Runx3 function to repress TrkB and promote the exclusive expression of TrkA and TrkC in nociceptors and proprioceptors, respectively.
Runx1 Negative_regulation (repress) of TrkB in nociceptors associated with nociceptor
1) Confidence 0.60 Published 2010 Journal Neural Dev Section Body Doc Link PMC2829025 Disease Relevance 0.38 Pain Relevance 0.42
Given the ability of Runx1 to repress TrkB [23], it is very likely that the failure to discriminate TrkA+ and TrkB+ neural identities in the Brn3a-/- TG is due to the loss of Runx1 function, and that Runx1 performs an analogous function in nociceptor precursors to that of Runx3 in the TrkC lineage.
Runx1 Negative_regulation (repress) of TrkB in neural associated with nociceptor and trigeminal ganglion
2) Confidence 0.39 Published 2010 Journal Neural Dev Section Body Doc Link PMC2829025 Disease Relevance 0.71 Pain Relevance 0.45

General Comments

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