INT298292

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Context Info
Confidence 0.35
First Reported 2010
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 1
Total Number 3
Disease Relevance 1.36
Pain Relevance 1.09

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytoplasm (Runx3, Ntrk3) cell differentiation (Ntrk3) plasma membrane (Ntrk3)
nucleus (Runx3) DNA binding (Runx3) kinase activity (Ntrk3)
Anatomy Link Frequency
embryos 2
nociceptors 2
Runx3 (Mus musculus)
Ntrk3 (Mus musculus)
Pain Link Frequency Relevance Heat
nociceptor 96 99.84 Very High Very High Very High
trigeminal ganglion 225 98.16 Very High Very High Very High
Acute pain 3 13.84 Low Low
calcitonin gene related peptide 33 8.96 Low Low
Neuropeptide 12 5.00 Very Low Very Low Very Low
mu opioid receptor 12 5.00 Very Low Very Low Very Low
substance P 9 5.00 Very Low Very Low Very Low
Somatostatin 9 5.00 Very Low Very Low Very Low
Central nervous system 6 5.00 Very Low Very Low Very Low
Spinal cord 6 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Ganglion Cysts 255 98.16 Very High Very High Very High
Targeted Disruption 129 85.20 High High
Repression 21 73.48 Quite High
Pain 9 13.84 Low Low
Nociception 9 10.08 Low Low
Neurodegenerative Disease 9 5.00 Very Low Very Low Very Low
Death 6 5.00 Very Low Very Low Very Low
Herpes Simplex Virus 3 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Thus, it is likely that both Runx1 and Runx3 function to repress TrkB and promote the exclusive expression of TrkA and TrkC in nociceptors and proprioceptors, respectively.
Runx3 Positive_regulation (promote) of Gene_expression (expression) of TrkC in nociceptors associated with nociceptor
1) Confidence 0.35 Published 2010 Journal Neural Dev Section Body Doc Link PMC2829025 Disease Relevance 0.40 Pain Relevance 0.43
In Brn3a-/- TG, TrkC expression is initiated normally, although Runx3 is never expressed, indicating that Runx3 is necessary for the maintenance but not the onset of TrkC expression, consistent with prior results in Runx3-/- embryos [34].
Runx3 Neg (not) Positive_regulation (necessary) of Gene_expression (expression) of TrkC in embryos associated with trigeminal ganglion
2) Confidence 0.35 Published 2010 Journal Neural Dev Section Body Doc Link PMC2829025 Disease Relevance 0.66 Pain Relevance 0.46
Loss of Runx3 may lead to the failure of TrkB and TrkC to segregate into distinct lineages, consistent with previous work demonstrating that Runx3 represses TrkB expression while promoting expression of TrkC [23,44].
Runx3 Positive_regulation (promoting) of Gene_expression (expression) of TrkC
3) Confidence 0.31 Published 2010 Journal Neural Dev Section Body Doc Link PMC2829025 Disease Relevance 0.30 Pain Relevance 0.20

General Comments

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