INT298295

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Context Info
Confidence 0.38
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 0.45
Pain Relevance 0.86

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (Ntrk1) plasma membrane (Ntrk1) nucleus (Runx1)
DNA binding (Runx1) kinase activity (Ntrk1) transcription factor binding (Runx1)
Anatomy Link Frequency
nociceptor 4
Runx1 (Mus musculus)
Ntrk1 (Mus musculus)
Pain Link Frequency Relevance Heat
nociceptor 111 100.00 Very High Very High Very High
Neuropeptide 5 99.76 Very High Very High Very High
trigeminal ganglion 75 94.24 High High
superficial lamina 2 78.96 Quite High
Spinal cord 4 76.32 Quite High
TRP channel 1 71.48 Quite High
Kinase C 1 68.36 Quite High
Glutamate receptor 1 66.60 Quite High
Inflammation 14 50.00 Quite Low
Pain 19 38.20 Quite Low
Disease Link Frequency Relevance Heat
Ganglion Cysts 85 94.24 High High
Repression 7 73.88 Quite High
Targeted Disruption 57 53.08 Quite High
INFLAMMATION 14 50.00 Quite Low
Pain 23 38.20 Quite Low
Neuropathic Pain 44 5.00 Very Low Very Low Very Low
Inflammatory Pain 19 5.00 Very Low Very Low Very Low
Hyperalgesia 7 5.00 Very Low Very Low Very Low
Nervous System Injury 6 5.00 Very Low Very Low Very Low
Pressure And Volume Under Development 5 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
First, Runx1 is required to suppress the expression of a set of peptidergic nociceptor markers, such as TrkA, the neuropeptide CGRP [23], and the acid-sensing channel DRASIC [14,15,17].
Runx1 Negative_regulation (suppress) of Gene_expression (expression) of TrkA in nociceptor associated with nociceptor and neuropeptide
1) Confidence 0.38 Published 2010 Journal Mol Pain Section Body Doc Link PMC2919460 Disease Relevance 0.05 Pain Relevance 0.43
Thus, it is likely that both Runx1 and Runx3 function to repress TrkB and promote the exclusive expression of TrkA and TrkC in nociceptors and proprioceptors, respectively.
Runx1 Negative_regulation (promote) of Gene_expression (expression) of TrkA in nociceptors associated with nociceptor
2) Confidence 0.26 Published 2010 Journal Neural Dev Section Body Doc Link PMC2829025 Disease Relevance 0.39 Pain Relevance 0.43

General Comments

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