INT298298

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Context Info
Confidence 0.19
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.33
Pain Relevance 1.00

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (Calca, Runx1) extracellular space (Calca) extracellular region (Calca)
intracellular (Calca) DNA binding (Runx1) transcription factor binding (Runx1)
Anatomy Link Frequency
nociceptor 2
Calca (Mus musculus)
Runx1 (Mus musculus)
Pain Link Frequency Relevance Heat
calcitonin gene related peptide 11 100.00 Very High Very High Very High
Neuropeptide 4 99.66 Very High Very High Very High
nociceptor 32 98.02 Very High Very High Very High
mu opioid receptor 4 91.20 High High
trigeminal ganglion 75 89.60 High High
substance P 3 5.00 Very Low Very Low Very Low
Somatostatin 3 5.00 Very Low Very Low Very Low
Central nervous system 2 5.00 Very Low Very Low Very Low
Spinal cord 2 5.00 Very Low Very Low Very Low
Serotonin 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Ganglion Cysts 85 89.60 High High
Targeted Disruption 43 61.52 Quite High
Nociception 3 59.88 Quite High
Repression 7 24.84 Low Low
Pain 3 5.00 Very Low Very Low Very Low
Neurodegenerative Disease 3 5.00 Very Low Very Low Very Low
Death 2 5.00 Very Low Very Low Very Low
Herpes Simplex Virus 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The role of Runx1 in determining the final nociceptor gene expression profile is complex, in that the loss of Runx1 favors neuropeptide expression, and CGRP is repressed by ectopic expression of Runx1 [23], yet some functional genes associated with the peptidergic phenotype, such as Trpm8 and TrpA1, are Runx1-dependent [3].
CGRP Negative_regulation (repressed) of Gene_expression (expression) of Runx1 in nociceptor associated with calcitonin gene related peptide, nociceptor and neuropeptide
1) Confidence 0.19 Published 2010 Journal Neural Dev Section Body Doc Link PMC2829025 Disease Relevance 0.33 Pain Relevance 1.00

General Comments

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