INT298302

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Context Info
Confidence 0.03
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 3
Disease Relevance 1.87
Pain Relevance 0.14

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (CUX1) extracellular region (BDNF) Golgi apparatus (CUX1)
nucleolus (CUX1) nucleus (CUX1) cytoplasmic membrane-bounded vesicle (BDNF)
BDNF (Homo sapiens)
CUX1 (Homo sapiens)
Pain Link Frequency Relevance Heat
depression 3 96.80 Very High Very High Very High
Pain 3 5.00 Very Low Very Low Very Low
Hippocampus 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Death 3 99.40 Very High Very High Very High
Depression 3 96.80 Very High Very High Very High
Stress 168 88.48 High High
Anxiety Disorder 6 5.00 Very Low Very Low Very Low
Affective Disorder 6 5.00 Very Low Very Low Very Low
Pain 3 5.00 Very Low Very Low Very Low
Neuroblastoma 3 5.00 Very Low Very Low Very Low
Disease 3 5.00 Very Low Very Low Very Low
Injury 3 5.00 Very Low Very Low Very Low
Shock 3 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Binding of proBDNF to p75 promotes cell death and attenuates synaptic transmission by inducing long term depression [62,63], while mature BDNF sustains long term potentiation and cell survival [59,64,65].
proBDNF Binding (Binding) of p75 associated with depression and death
1) Confidence 0.03 Published 2010 Journal BMC Neurosci Section Body Doc Link PMC2829032 Disease Relevance 0.64 Pain Relevance 0.05
While proBDNF binds only to p75 receptor, mature BDNF displays high affinity to TrkB and lower affinity to p75 [61].
BDNF Binding (affinity) of p75
2) Confidence 0.03 Published 2010 Journal BMC Neurosci Section Body Doc Link PMC2829032 Disease Relevance 0.63 Pain Relevance 0.05
While proBDNF binds only to p75 receptor, mature BDNF displays high affinity to TrkB and lower affinity to p75 [61].
proBDNF Binding (binds) of p75
3) Confidence 0.03 Published 2010 Journal BMC Neurosci Section Body Doc Link PMC2829032 Disease Relevance 0.60 Pain Relevance 0.04

General Comments

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