INT29832

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Context Info
Confidence 0.37
First Reported 1984
Last Reported 2010
Negated 2
Speculated 0
Reported most in Body
Documents 20
Total Number 21
Disease Relevance 5.91
Pain Relevance 3.63

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (Scn7a)
Anatomy Link Frequency
neurons 2
urine 2
plasma 1
ileum 1
muscles 1
Scn7a (Mus musculus)
Pain Link Frequency Relevance Heat
tetrodotoxin 70 99.90 Very High Very High Very High
gABA 12 99.52 Very High Very High Very High
nav1.8 4 99.18 Very High Very High Very High
Mexiletine 1 98.52 Very High Very High Very High
sodium channel 11 97.04 Very High Very High Very High
Neuronal excitability 1 96.12 Very High Very High Very High
Calcium channel 6 93.96 High High
hyperexcitability 2 84.40 Quite High
Glutamate receptor 18 83.76 Quite High
addiction 29 83.40 Quite High
Disease Link Frequency Relevance Heat
Apoptosis 993 99.92 Very High Very High Very High
Death 228 99.90 Very High Very High Very High
Hypoxia 39 99.40 Very High Very High Very High
Colitis 36 98.54 Very High Very High Very High
Necrosis 51 98.04 Very High Very High Very High
Disease 109 94.92 High High
Neurodegenerative Disease 84 94.80 High High
Pressure And Volume Under Development 48 94.12 High High
Injury 19 85.12 High High
Diarrhoea 7 76.08 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
TTX and Na+ reduction were without effect on fibres incubated for 2 h in the control saline or on fibres depolarized by raising external K+ ion concentration.
Negative_regulation (reduction) of Na in external associated with tetrodotoxin
1) Confidence 0.37 Published 1988 Journal Q J Exp Physiol Section Abstract Doc Link 2845463 Disease Relevance 0 Pain Relevance 0.36
Abolishment of the Na+ gradient by removal of 120 mM extracellular Na+ reduced the upstroke potential frequency by 13 - 18% and its amplitude by 50 - 70% in the ileum.
Negative_regulation (removal) of Na in ileum
2) Confidence 0.28 Published 1995 Journal Can. J. Physiol. Pharmacol. Section Abstract Doc Link 8748943 Disease Relevance 0 Pain Relevance 0.45
Unmasking of a periodic Na+ entry into glucose-stimulated pancreatic beta-cells after partial inhibition of the Na/K pump.
Negative_regulation (inhibition) of Na
3) Confidence 0.22 Published 1998 Journal Endocrinology Section Title Doc Link 9645697 Disease Relevance 0 Pain Relevance 0.08
Partial suppression of the Na/K pump with 50 microM ouabain resulted in oscillations of [Na+]i in 65% of the cells (frequency, 0.13+/-O.O1 min(-l); amplitude, 4.4 +/-0.3 mM).
Negative_regulation (suppression) of Na
4) Confidence 0.22 Published 1998 Journal Endocrinology Section Abstract Doc Link 9645697 Disease Relevance 0 Pain Relevance 0.08
Loperamide inhibited intestinal Na+, K+-ATPase activity, whilst sucrase activity was unaffected.
Negative_regulation (inhibited) of Na
5) Confidence 0.08 Published 2000 Journal J. Pharm. Pharmacol. Section Abstract Doc Link 10875545 Disease Relevance 0 Pain Relevance 0.06
The overshoot disappeared in the presence of phlorizin or when Na+ was replaced by K+.
Negative_regulation (replaced) of Na
6) Confidence 0.08 Published 2000 Journal J. Pharm. Pharmacol. Section Abstract Doc Link 10875545 Disease Relevance 0 Pain Relevance 0.08
4 M ouabain (Merck) in order to inhibit Na+/K+ATPase activity, with or without 3 × 10?
Negative_regulation (inhibit) of Na
7) Confidence 0.04 Published 2008 Journal The Journal of General Physiology Section Body Doc Link PMC2483333 Disease Relevance 0 Pain Relevance 0.10
Interestingly, after one week of DSS treatment, the acute colitis did not compromise the secretory function of the epithelium at all, but abolished the Na+ absorptive function completely.
Neg (not) Negative_regulation (abolished) of Na in epithelium associated with colitis
8) Confidence 0.04 Published 2007 Journal PLoS ONE Section Body Doc Link PMC2110898 Disease Relevance 0.51 Pain Relevance 0.09
L-2,4-Diaminobutyric acid, an inhibitor of the Na+-dependent GABA carrier, did not affect the releasing action of EGTA, whereas in a parallel experiment this drug inhibited by more than 90% the exchange of labeled GABA with unlabeled GABA.
Negative_regulation (inhibitor) of Na in L-2 associated with gaba
9) Confidence 0.04 Published 1984 Journal J. Neurochem. Section Abstract Doc Link 6144725 Disease Relevance 0 Pain Relevance 0.67
20 mV, used to achieve inactivation of the Na+ channels, followed by a return to the voltage of ?
Negative_regulation (inactivation) of Na
10) Confidence 0.04 Published 2008 Journal Prog Biophys Mol Biol Section Body Doc Link PMC2764399 Disease Relevance 0 Pain Relevance 0.03
The slow TTX-R-inactivating Na current density (Nav1.8) was significantly increased, but other Na currents were unaffected.
Neg (unaffected) Negative_regulation (unaffected) of Na associated with nav1.8
11) Confidence 0.04 Published 2004 Journal Am. J. Physiol. Gastrointest. Liver Physiol. Section Abstract Doc Link 15205116 Disease Relevance 0.51 Pain Relevance 0.61
9 M had no significant effect on control muscles, it produced a significant reduction of Na+ entry in mdx5cv muscles (30%, Fig. 1).
Negative_regulation (reduction) of Na in muscles
12) Confidence 0.04 Published 2008 Journal The Journal of General Physiology Section Body Doc Link PMC2483333 Disease Relevance 0 Pain Relevance 0.28
Similar effect of TTX has been reported in neurons, where it reduced neuronal death and blocked Na+ entry during hypoxia, improving survival of cultured neocortical neurons (Banasiak et al., 2004).
Negative_regulation (blocked) of Na in neurons associated with tetrodotoxin, hypoxia and death
13) Confidence 0.04 Published 2008 Journal The Journal of General Physiology Section Body Doc Link PMC2483333 Disease Relevance 0.51 Pain Relevance 0.42
Third, the removal of extracellular Ca2+ and Na+ eliminated the current induced by urine stimulation.
Negative_regulation (removal) of Na in urine
14) Confidence 0.03 Published 2010 Journal The Journal of General Physiology Section Body Doc Link PMC2806418 Disease Relevance 0 Pain Relevance 0
As shown in Fig. 3 (B and D), when [Na+]o was decreased from 138 to 20 mM, there was no significant change in reversal potential for the urine response (reversal potential of urine response in Ringer's vs. low Na Ringer's: 2.83 ± 0.93 mV vs. 2.00 ± 0.58 mV; t(2) = 0.56; P = 0.630; paired t test; n = 3).
Negative_regulation (decreased) of Na in urine
15) Confidence 0.03 Published 2010 Journal The Journal of General Physiology Section Body Doc Link PMC2806418 Disease Relevance 0 Pain Relevance 0.06
Similarly, significant downregulation of Na+/K+-ATPase mRNA was observed from our real-time PCR data at the onset of lactacystine-, staurosporine- and colchicine-mediated apoptosis (Fig. 3).
Negative_regulation (downregulation) of Na associated with apoptosis
16) Confidence 0.01 Published 2008 Journal Current Neuropharmacology Section Body Doc Link PMC2647147 Disease Relevance 0.61 Pain Relevance 0.07
Ouabain, a cardiac glycoside, is commonly used to treat cells to induce inhibition of Na+/K+-ATPase.
Negative_regulation (inhibition) of Na
17) Confidence 0.01 Published 2008 Journal Current Neuropharmacology Section Body Doc Link PMC2647147 Disease Relevance 0.74 Pain Relevance 0.04
The initial rise in intracellular Na+ is suggested to be contributed by two major sources: the inhibition of the Na+/K+-ATPase and the opening of the plasma membrane Na+ channels.
Negative_regulation (inhibition) of Na in plasma
18) Confidence 0.01 Published 2008 Journal Current Neuropharmacology Section Body Doc Link PMC2647147 Disease Relevance 0.86 Pain Relevance 0
Since compelling evidence demonstrated that Na+/K+-ATPase is involved in the rectification of perturbed K+ and Na+ ion homeostasis during apoptosis, a loss of Na+/K+-ATPase function is naturally required for programmed cell death to proceed.
Negative_regulation (loss) of Na associated with apoptosis
19) Confidence 0.01 Published 2008 Journal Current Neuropharmacology Section Body Doc Link PMC2647147 Disease Relevance 0.67 Pain Relevance 0.09
A recent study indicated that lack of tyrosine phosphorylation can inhibit the activity of Na+/K+-ATPase in cortical neurons, eventually resulting apoptosis [133].
Negative_regulation (inhibit) of Na in neurons associated with apoptosis
20) Confidence 0.01 Published 2008 Journal Current Neuropharmacology Section Body Doc Link PMC2647147 Disease Relevance 0.67 Pain Relevance 0.04

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