INT29833

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.27
First Reported 1988
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 39
Total Number 40
Disease Relevance 19.40
Pain Relevance 1.74

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytoskeleton (Spna1) molecular_function (Spna1) cytoplasm (Spna1)
Anatomy Link Frequency
neurons 3
erythrocytes 2
articular 1
leg 1
immune system 1
Spna1 (Mus musculus)
Pain Link Frequency Relevance Heat
fortral 4 99.98 Very High Very High Very High
gABA 26 99.64 Very High Very High Very High
Inflammation 20 99.40 Very High Very High Very High
adenocard 6 99.32 Very High Very High Very High
Pain 17 96.28 Very High Very High Very High
GABA receptor 2 96.16 Very High Very High Very High
imagery 52 93.72 High High
Action potential 40 87.40 High High
agonist 40 81.84 Quite High
Opioid 1 81.60 Quite High
Disease Link Frequency Relevance Heat
Influenza Virus Infection 1161 100.00 Very High Very High Very High
Cognitive Disorder 45 100.00 Very High Very High Very High
Targeted Disruption 30 99.72 Very High Very High Very High
Infection 387 99.58 Very High Very High Very High
INFLAMMATION 27 99.40 Very High Very High Very High
Immunization 279 99.04 Very High Very High Very High
Synovitis 3 98.88 Very High Very High Very High
B-cell Lymphoma 1 98.68 Very High Very High Very High
Calcification 3 98.38 Very High Very High Very High
Sprains And Strains 476 98.36 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Long under-assessed, NMF are now recognized as frequent and sometimes involving a greater degree of disability than motor fluctuations.
NMF Binding (recognized) of
1) Confidence 0.27 Published 2007 Journal Rev. Neurol. (Paris) Section Abstract Doc Link 17878814 Disease Relevance 0.71 Pain Relevance 0.23
HA induced memory impairment in our study and this impairment was greater in the presence of A?
HA Neg (impairment) Binding (impairment) of associated with cognitive disorder
2) Confidence 0.22 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2808336 Disease Relevance 1.55 Pain Relevance 0.16
Although painful periarticular tendinous calcification (peritendinitis calcarea) resulting from the deposition of calcium HA crystals has long been recognized, it has only recently been discovered that intra-articular HA can be associated with an acute inflammatory synovitis.
intra-articular HA Binding (associated) of in articular associated with pain, calcification, inflammation and synovitis
3) Confidence 0.16 Published 1988 Journal Radiol. Clin. North Am. Section Abstract Doc Link 2845468 Disease Relevance 1.70 Pain Relevance 0.18
Mice were immunized intranasally with H5N1 VLPs containing 0.1 µg or 0.3 µg H5 HA and a boost was given 4 weeks after the priming dose.
HA Binding (immunized) of
4) Confidence 0.10 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2646145 Disease Relevance 0.67 Pain Relevance 0
Mice vaccinated with VLPs had one population of antibody that bound specifically to each homologous HA at an apparent association rate (ka1) that ranged from 1.55×104 to 1.65×105, regardless of the vaccine strain (Viet Nam clade 1 or Indonesia clade 2) or the route of vaccination (IM or IN).
HA Binding (bound) of associated with sprains and strains
5) Confidence 0.10 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2200794 Disease Relevance 0.21 Pain Relevance 0
The increase in antibody association rates in vivo could bind HA on viruses quickly and perhaps decrease the number of infected cells in the lung, and thus could act to reduce the amount of viral replication to allow the immune system opportunity to better control the infection.
HA Binding (bind) of in immune system associated with infection
6) Confidence 0.10 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2200794 Disease Relevance 0.56 Pain Relevance 0
Each serum sample was also tested for binding to the cross-clade HA in an ELISA.
HA Binding (binding) of
7) Confidence 0.10 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2200794 Disease Relevance 0 Pain Relevance 0
Most neutralizing antibodies recognize hemagglutinin (HA), which is the major surface glycoprotein of influenza viruses.
HA Binding (recognize) of associated with influenza virus infection
8) Confidence 0.08 Published 2009 Journal PLoS Pathogens Section Body Doc Link PMC2652660 Disease Relevance 0.57 Pain Relevance 0
The VTM neurons of HDC-KO mice showed no histamine immunoreactivity, but were immunoreactive for the histaminergic (HA) neuron markers adenosine deaminase and glutamic acid decarboxylase 67.
HA Binding (immunoreactive) of in neurons associated with adenocard
9) Confidence 0.08 Published 2010 Journal Frontiers in Behavioral Neuroscience Section Abstract Doc Link PMC2972729 Disease Relevance 0.17 Pain Relevance 0.11
At present, it is unclear whether HA axons release GABA both synaptically and non-synaptically and affect both synaptic and extrasynaptic GABA receptors, thereby having a significant inhibitory effect on target neurons.
HA Binding (axons) of in neurons associated with gaba and gaba receptor
10) Confidence 0.08 Published 2010 Journal Frontiers in Behavioral Neuroscience Section Body Doc Link PMC2972729 Disease Relevance 0.22 Pain Relevance 0.39
At week 5, mice vaccinated intramuscularly with VLPs or rHA had anti-HA antibodies that recognized the homologous rHA-coated plates with endpoint dilution titers that ranged between 104-105 (i.e. antibodies elicited by an Indonesia-derived vaccine binding to HA in an Indonesia rHA-specific ELISA) (Table 1).
HA Binding (binding) of
11) Confidence 0.07 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2200794 Disease Relevance 0 Pain Relevance 0
However, an apparent association rate of antibody binding to HA correlated with protection and was enhanced using VLPs, particularly when delivered intranasally, compared to rHA vaccines.


HA Binding (binding) of
12) Confidence 0.07 Published 2008 Journal PLoS ONE Section Abstract Doc Link PMC2200794 Disease Relevance 0.68 Pain Relevance 0
In contrast, low fluorescence was observed in the contra-lateral leg and the corresponding lymph node, indicating migration of some HA-specific CTLs at sites not expressing HA.
HA Binding (migration) of in leg
13) Confidence 0.07 Published 2007 Journal PLoS ONE Section Body Doc Link PMC2034600 Disease Relevance 0.79 Pain Relevance 0
Since we assume that MAb S139/1 recognizes a single epitope on the HA molecules of all the subtypes, it is likely that the different binding affinity of MAb S139/1 to each HA subtype influences the neutralization and HI activities.
HA Binding (recognizes) of
14) Confidence 0.06 Published 2009 Journal PLoS Pathogens Section Body Doc Link PMC2652660 Disease Relevance 0.30 Pain Relevance 0
Thus, it might be of interest to clarify whether the reactivity of MAb S139/1 to multiple HA suptypes is affected by changes of HA receptor recognition associated with substitutions around this epitope.
HA Binding (recognition) of
15) Confidence 0.06 Published 2009 Journal PLoS Pathogens Section Body Doc Link PMC2652660 Disease Relevance 0.27 Pain Relevance 0
MAb S139/1 bound to HA molecules under non-reducing conditions, whereas it bound very weakly to HA1 but not HA2 under reducing conditions (data not shown), suggesting that MAb S139/1 recognized a conformational epitope on the HA1 subunit of the HA molecule.
HA Binding (bound) of
16) Confidence 0.06 Published 2009 Journal PLoS Pathogens Section Body Doc Link PMC2652660 Disease Relevance 1.11 Pain Relevance 0
A molecular modeling study showed that these amino acids were located on the globular head of the HA and formed a novel conformational epitope adjacent to the receptor-binding domain of HA.
HA Binding (binding) of in head
17) Confidence 0.06 Published 2009 Journal PLoS Pathogens Section Abstract Doc Link PMC2652660 Disease Relevance 0.68 Pain Relevance 0
Most neutralizing antibodies recognize hemagglutinin (HA), which is the major surface glycoprotein of influenza viruses.
HA Binding (recognize) of associated with influenza virus infection
18) Confidence 0.06 Published 2009 Journal PLoS Pathogens Section Abstract Doc Link PMC2652660 Disease Relevance 0.97 Pain Relevance 0
In vitro translation yielded a protein of approximately 28 kDa, as did transfection of a probe containing the hemagglutinin (HA) epitope (S2-1a.HA) into CHO cells, as determined by western analysis using an antibody directed against HA. (+)-[3H]-Pentazocine binding to immunopurified HA-tagged receptor demonstrated conclusively that S2-1a.HA encodes a high-affinity (+)-[3H]pentazocine binding site with characteristics of a murine sigma1 receptor.
HA Binding (binding) of associated with fortral
19) Confidence 0.05 Published 1998 Journal J. Neurochem. Section Abstract Doc Link 9603192 Disease Relevance 0 Pain Relevance 0.45
For example, S193R substitution on prototype H3 human virus HA altered binding specificity by acquiring the ability to agglutinate erythrocytes containing SA?
HA Binding (binding) of in erythrocytes
20) Confidence 0.05 Published 2009 Journal PLoS Pathogens Section Body Doc Link PMC2652660 Disease Relevance 0.08 Pain Relevance 0

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox