INT298340

Context Info Confidence 0.49 First Reported 2010 Last Reported 2010 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 1 Disease Relevance 0.06 Pain Relevance 0.03

nucleus (HES3) DNA binding (HES3) transcription factor binding (HES3)

HES3 (Homo sapiens)

Pain Link Frequency Relevance Heat Central nervous system 9 57.28 Spinal cord 1 32.08 midbrain 4 24.16 Dopamine 5 5.00 Substantia nigra 2 5.00 cerebral cortex 1 5.00 Perioperative pain 1 5.00 Hippocampus 1 5.00

Disease Link Frequency Relevance Heat Cancer 10 59.92 Stroke 3 5.00 Neurological Disease 2 5.00 Disease 1 5.00 Injury 1 5.00 Post Operative Pain 1 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

In vitro, Ang2 induces STAT3-Ser phosphorylation and we have shown that this event leads to Hes3 transcription and subsequent sonic hedgehog expression [31].

Transcription (transcription) of Hes3

1) Confidence 0.49 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2829079 Disease Relevance 0.06 Pain Relevance 0.03

General Comments

This test has worked.