INT298342

Context Info Confidence 0.32 First Reported 2010 Last Reported 2010 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 1 Disease Relevance 0.13 Pain Relevance 0.05

nucleus (HES3) DNA binding (HES3) transcription factor binding (HES3)

Anatomy Link Frequency Notch 1 HES3 (Homo sapiens)

Pain Link Frequency Relevance Heat Central nervous system 9 90.08 Hippocampus 1 44.64 midbrain 4 27.60 Dopamine 5 26.88 Substantia nigra 2 5.00 cerebral cortex 1 5.00 Spinal cord 1 5.00 Perioperative pain 1 5.00

Disease Link Frequency Relevance Heat Stroke 3 82.00 Injury 1 52.80 Cancer 10 31.68 Neurological Disease 2 5.00 Disease 1 5.00 Post Operative Pain 1 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

This pathway links the Notch receptor to phosphorylation of STAT3 on the serine residue and a subsequent rapid increase in the transcription factor Hes3 that causes a long lasting elevation of sonic hedgehog (Shh).

Positive_regulation (increase) of Hes3 in Notch

1) Confidence 0.32 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2829079 Disease Relevance 0.13 Pain Relevance 0.05

General Comments

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