INT298343

Context Info Confidence 0.33 First Reported 2010 Last Reported 2010 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 1 Disease Relevance 0.33 Pain Relevance 0.08

nucleus (HES3) DNA binding (HES3) transcription factor binding (HES3)

Anatomy Link Frequency stem cells 1 HES3 (Homo sapiens)

Pain Link Frequency Relevance Heat Central nervous system 9 98.64 cerebral cortex 1 26.40 midbrain 4 20.96 Dopamine 5 20.24 Spinal cord 1 12.16 Substantia nigra 2 5.00 Perioperative pain 1 5.00 Hippocampus 1 5.00

Disease Link Frequency Relevance Heat Cancer 10 99.96 Stroke 3 5.00 Neurological Disease 2 5.00 Disease 1 5.00 Injury 1 5.00 Post Operative Pain 1 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Here, in addition to previously defined self-renewal markers, we used Hes3 expression to assess fast changes in cell state and to determine if Hes3 also recognizes cancer stem cells arising in the CNS.

Hes3 Binding (recognizes) of in stem cells associated with cancer and central nervous system

1) Confidence 0.33 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2829079 Disease Relevance 0.33 Pain Relevance 0.08

General Comments

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