INT298347

Context Info Confidence 0.34 First Reported 2010 Last Reported 2010 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 4 Disease Relevance 0.72 Pain Relevance 0.34

nucleus (HES3) DNA binding (HES3) transcription factor binding (HES3)

Anatomy Link Frequency brain 4 HES3 (Homo sapiens)

Pain Link Frequency Relevance Heat Central nervous system 36 89.64 Spinal cord 4 61.48 cerebral cortex 4 55.20 midbrain 16 53.56 Dopamine 20 49.04 Substantia nigra 8 5.00 Perioperative pain 4 5.00 Hippocampus 4 5.00

Disease Link Frequency Relevance Heat Cancer 40 96.12 Stroke 12 5.00 Neurological Disease 8 5.00 Disease 4 5.00 Injury 4 5.00 Post Operative Pain 4 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Fetal mouse NSCs prospectively isolated by prominin expression are six fold enriched for Hes3 expression (6.42±1.9, n?

Positive_regulation (by) of Gene_expression (expression) of Hes3

1) Confidence 0.34 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2829079 Disease Relevance 0.36 Pain Relevance 0.11

Fetal mouse NSCs prospectively isolated by prominin expression are six fold enriched for Hes3 expression (6.42±1.9, n?

Positive_regulation (enriched) of Gene_expression (expression) of Hes3

2) Confidence 0.34 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2829079 Disease Relevance 0.36 Pain Relevance 0.11

NSCs from the adult rodent and monkey brain express Hes3; differentiation causes a rapid loss of Hes3 expression [6].

Positive_regulation (causes) of Gene_expression (expression) of Hes3 in brain

3) Confidence 0.32 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2829079 Disease Relevance 0 Pain Relevance 0.06

NSCs from the adult rodent and monkey brain express Hes3; differentiation causes a rapid loss of Hes3 expression [6].

Positive_regulation (causes) of Gene_expression (express) of Hes3 in brain

4) Confidence 0.32 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2829079 Disease Relevance 0 Pain Relevance 0.06

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