INT298348

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Context Info
Confidence 0.18
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 0.14
Pain Relevance 0.28

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (ANGPT2, Stat3) plasma membrane (ANGPT2, Stat3) cell differentiation (ANGPT2)
DNA binding (Stat3) cytoplasm (Stat3) signal transducer activity (Stat3)
Anatomy Link Frequency
stem cell 2
ANGPT2 (Homo sapiens)
Stat3 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Central nervous system 18 99.08 Very High Very High Very High
midbrain 8 87.44 High High
Dopamine 10 86.72 High High
Spinal cord 2 35.36 Quite Low
Hippocampus 2 14.76 Low Low
Substantia nigra 4 5.00 Very Low Very Low Very Low
cerebral cortex 2 5.00 Very Low Very Low Very Low
Perioperative pain 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Stroke 6 81.36 Quite High
Cancer 20 54.96 Quite High
Injury 2 22.92 Low Low
Neurological Disease 4 5.00 Very Low Very Low Very Low
Disease 2 5.00 Very Low Very Low Very Low
Post Operative Pain 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In vitro, Ang2 induces STAT3-Ser phosphorylation and we have shown that this event leads to Hes3 transcription and subsequent sonic hedgehog expression [31].
Ang2 Positive_regulation (induces) of Phosphorylation (phosphorylation) of STAT3
1) Confidence 0.18 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2829079 Disease Relevance 0.05 Pain Relevance 0.03
Similar to Dll4, Ang2 also induces phosphorylation of STAT3 on the serine residue, in fetal neural stem cell cultures.
Ang2 Positive_regulation (induces) of Phosphorylation (phosphorylation) of STAT3 in stem cell
2) Confidence 0.12 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2829079 Disease Relevance 0.08 Pain Relevance 0.25

General Comments

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