INT298349

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Context Info
Confidence 0.12
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.14
Pain Relevance 0.07

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (HES3, Shh) anatomical structure formation involved in morphogenesis (Shh) embryo development (Shh)
DNA binding (HES3) anatomical structure development (Shh) peptidase activity (Shh)
Anatomy Link Frequency
Notch 1
HES3 (Homo sapiens)
Shh (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Central nervous system 9 94.88 High High
Hippocampus 1 43.16 Quite Low
midbrain 4 32.40 Quite Low
Dopamine 5 31.68 Quite Low
Substantia nigra 2 5.00 Very Low Very Low Very Low
cerebral cortex 1 5.00 Very Low Very Low Very Low
Spinal cord 1 5.00 Very Low Very Low Very Low
Perioperative pain 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Stroke 3 86.80 High High
Injury 1 51.32 Quite High
Cancer 10 30.20 Quite Low
Neurological Disease 2 5.00 Very Low Very Low Very Low
Disease 1 5.00 Very Low Very Low Very Low
Post Operative Pain 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
This pathway links the Notch receptor to phosphorylation of STAT3 on the serine residue and a subsequent rapid increase in the transcription factor Hes3 that causes a long lasting elevation of sonic hedgehog (Shh).
Hes3 Positive_regulation (elevation) of Shh in Notch
1) Confidence 0.12 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2829079 Disease Relevance 0.14 Pain Relevance 0.07

General Comments

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