INT29835

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Context Info
Confidence 0.50
First Reported 1988
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 7
Total Number 7
Disease Relevance 3.92
Pain Relevance 2.57

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (TBXA2R) signal transducer activity (TBXA2R)
Anatomy Link Frequency
monocytes 2
PGE2 2
TBXA2R (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 88 100.00 Very High Very High Very High
aspirin 17 99.74 Very High Very High Very High
COX2 2 99.74 Very High Very High Very High
COX-2 inhibitor 16 98.04 Very High Very High Very High
cINOD 35 97.28 Very High Very High Very High
cytokine 2 94.64 High High
Inflammatory response 1 75.00 Quite High
Inflammatory mediators 16 74.56 Quite High
licofelone 12 65.84 Quite High
Pain 6 49.68 Quite Low
Disease Link Frequency Relevance Heat
INFLAMMATION 121 100.00 Very High Very High Very High
Injury 28 99.60 Very High Very High Very High
Death 2 98.48 Very High Very High Very High
Hemorrhage 18 97.44 Very High Very High Very High
Stroke 3 96.20 Very High Very High Very High
Myocardial Infarction 3 95.40 Very High Very High Very High
Volume Depletion And Dehydration 1 94.72 High High
Thrombosis 8 93.28 High High
Increased Venous Pressure Under Development 8 87.12 High High
Necrosis 2 86.80 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
TXA2 synthesis is immediate and dependent on cyclooxygenase Type 1 (COX-1) activity whereas PGE2 synthesis is delayed and dependent on COX-2 activity.
Regulation (dependent) of Gene_expression (synthesis) of TXA2 in PGE2
1) Confidence 0.50 Published 2001 Journal Inflamm. Res. Section Abstract Doc Link 11409487 Disease Relevance 0.35 Pain Relevance 0.24
When the relative IC50 of COX inhibitors increased above 10, we observed a strong inhibition on the production of PGI2, whereas the production of TXA2 was hardly affected.
Regulation (affected) of Gene_expression (production) of TXA2
2) Confidence 0.35 Published 2008 Journal Mol Syst Biol Section Body Doc Link PMC2673713 Disease Relevance 0.50 Pain Relevance 0.43
COX-1 is the main COX isozyme in PLT, which is responsible for the major production of TXA2 in the model.
Regulation (responsible) of Gene_expression (production) of TXA2
3) Confidence 0.35 Published 2008 Journal Mol Syst Biol Section Body Doc Link PMC2673713 Disease Relevance 0.63 Pain Relevance 0.68
When the relative IC50(COX-1:COX-2) increases, the inhibition effect of the medicine on TXA2 production and PLT aggregation decreases when compared with their inhibition effect on PGI2 production (Sun and Li, 2000; Van Hecken et al, 2000).
Regulation (effect) of Gene_expression (production) of TXA2
4) Confidence 0.30 Published 2008 Journal Mol Syst Biol Section Body Doc Link PMC2673713 Disease Relevance 0.55 Pain Relevance 0.57
Differential regulation of prostaglandin E2 and thromboxane A2 production in human monocytes: implications for the use of cyclooxygenase inhibitors.
Regulation (regulation) of Gene_expression (production) of thromboxane A2 in monocytes associated with aspirin
5) Confidence 0.18 Published 2000 Journal J. Immunol. Section Title Doc Link 10903770 Disease Relevance 0.06 Pain Relevance 0.25
In short-term incubations, D-penicillamine and aurothiomalate did not affect leukotriene B4 (LTB4), prostaglandin E2 (PGE2) or thromboxane B2 (TXB2) production.
Neg (not) Regulation (affect) of Gene_expression (production) of thromboxane B2
6) Confidence 0.11 Published 1988 Journal Agents Actions Section Abstract Doc Link 2845746 Disease Relevance 0.10 Pain Relevance 0.29
Generation of oxygen free radicals, production of prostaglandins and thromboxane A2, release of proteolytic enzymes, and generalized inflammation are the underlying mechanical effects of these injuries.
Regulation (effects) of Gene_expression (production) of thromboxane A2 associated with inflammation and injury
7) Confidence 0.09 Published 2010 Journal Eplasty Section Body Doc Link PMC2873703 Disease Relevance 1.74 Pain Relevance 0.12

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