INT298355

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Context Info
Confidence 0.24
First Reported 2010
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 5
Total Number 5
Disease Relevance 2.98
Pain Relevance 0.32

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (CD83) plasma membrane (CD83)
Anatomy Link Frequency
CD86 2
blood 1
monocyte 1
CD83 (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 82 95.04 Very High Very High Very High
cytokine 46 81.76 Quite High
chemokine 22 73.56 Quite High
agonist 1 69.60 Quite High
imagery 72 67.48 Quite High
Central nervous system 21 52.16 Quite High
Chronic pancreatitis 21 35.44 Quite Low
pruritus 1 24.48 Low Low
positron emission tomography 24 5.00 Very Low Very Low Very Low
Pain 16 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cancer 357 99.60 Very High Very High Very High
Adenocarcinoma 180 99.20 Very High Very High Very High
Carcinoma 4 95.52 Very High Very High Very High
INFLAMMATION 88 95.04 Very High Very High Very High
Viral Meningitis 4 85.84 High High
Cold Sores 367 85.24 High High
Necrosis 7 71.08 Quite High
Glioma 45 70.12 Quite High
Adhesions 1 69.08 Quite High
Meningitis 1 66.40 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The modulation of the cell surface molecules CD86, CD83 and HLA-DR was measured after DC exposure to known photoallergenic and phototoxic as well as allergenic and non-allergenic chemicals or to irradiation only.
Regulation (modulation) of CD83 in CD86
1) Confidence 0.24 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3009729 Disease Relevance 0.07 Pain Relevance 0.04
We assessed if levels of the maturation marker CD83, costimulatory molecule CD40, and HLA DR on blood MDCs and PDCs were affected by the presence of PDAC.
Regulation (affected) of CD83 in blood associated with adenocarcinoma
2) Confidence 0.16 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2955544 Disease Relevance 0.77 Pain Relevance 0.05
The removal of the tumor had no or very low effect on CD83 levels when measured ?
Neg (no) Regulation (effect) of CD83 associated with cancer
3) Confidence 0.16 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2955544 Disease Relevance 0.88 Pain Relevance 0.03
Recently, it has been shown that the complex of the four glycoproteins gB, gD, gH and gL, which are essential for viral attachment/entry (Fig. 3), expressed on the surface of Cos7 cells mediates monocyte-derived DC recognition via a nucleic acid-independent and TLR-independent pathway, leading to the up-regulation of CD40, CD83, CD86 and HLA-DR and to the production of IFN-?
Regulation (regulation) of CD83 in monocyte
4) Confidence 0.11 Published 2010 Journal The Open Virology Journal Section Body Doc Link PMC2936037 Disease Relevance 0.77 Pain Relevance 0.10
At day 5, U-251 tumor cell lysate was added to the generated immature DCs and by day 6, cell started exhibiting morphological changes that were accompanied with the further changes in the expression of DCs' phenotypical markers such as CD83, CD86, HLA-DR (Figure 1, Supplemental material, Table S1).
Regulation (changes) of CD83 in CD86 associated with cancer
5) Confidence 0.05 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2829084 Disease Relevance 0.50 Pain Relevance 0.10

General Comments

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