INT29837

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.67
First Reported 1980
Last Reported 2004
Negated 1
Speculated 0
Reported most in Abstract
Documents 6
Total Number 8
Disease Relevance 0
Pain Relevance 3.53

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Gnrh1) extracellular region (Gnrh1) molecular_function (Gnrh1)
Anatomy Link Frequency
plasma 1
vessels 1
Gnrh1 (Rattus norvegicus)
LH (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Clonidine 7 100.00 Very High Very High Very High
narcan 11 99.36 Very High Very High Very High
Nicotine 9 98.82 Very High Very High Very High
Morphine 12 98.76 Very High Very High Very High
opiate 8 96.48 Very High Very High Very High
Neurotransmitter 1 85.08 High High
antagonist 9 82.84 Quite High
Endogenous opioid 2 82.60 Quite High
long acting opioid 1 82.08 Quite High
opioid receptor 1 75.68 Quite High
Disease Link Frequency Relevance Heat
Reprotox - General 2 2 25.00 Low Low
Cancer 1 25.00 Low Low
Precocious Puberty 1 25.00 Low Low
Galactorrhea 1 25.00 Low Low
Syndrome 1 25.00 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
A modest facilitation of LHRH-evoked increases in serum LH was also observed, but our data suggest that this represents only a minor component of opiate-induced enhancements of naloxone's effects.
LHRH-evoked Positive_regulation (increases) of LH associated with narcan and opiate
1) Confidence 0.67 Published 1984 Journal Eur. J. Pharmacol. Section Abstract Doc Link 6096156 Disease Relevance 0 Pain Relevance 1.21
Increase in the serum LH induced by exogenous LHRH was slightly potentiated and not inhibited by a large dose of morphine, in both intact and castrated rats.
LHRH Positive_regulation (induced) of serum LH associated with morphine
2) Confidence 0.58 Published 1980 Journal Arch Int Pharmacodyn Ther Section Abstract Doc Link 6776920 Disease Relevance 0 Pain Relevance 0.99
In stimulated conditions, i.c.v. administration of CDP-choline (1 micromol, i.c.v.) produced an increase in clonidine-stimulated GH, thyrotyropin-releasing hormone (TRH)-stimulated TSH, LH-releasing hormone (LHRH)-stimulated LH, but not FSH levels.
LHRH Positive_regulation (increase) of LH associated with clonidine
3) Confidence 0.37 Published 2004 Journal Fundam Clin Pharmacol Section Abstract Doc Link 15482372 Disease Relevance 0 Pain Relevance 0.19
Nicotine treatment blocked naloxone induced LH release and reduced LHRH induced increases in serum LH.
LHRH Positive_regulation (increases) of LH associated with nicotine and narcan
4) Confidence 0.33 Published 1997 Journal Life Sci. Section Abstract Doc Link 9194685 Disease Relevance 0 Pain Relevance 0.65
In stimulated conditions, i.c.v. administration of CDP-choline (1 micromol, i.c.v.) produced an increase in clonidine-stimulated GH, thyrotyropin-releasing hormone (TRH)-stimulated TSH, LH-releasing hormone (LHRH)-stimulated LH, but not FSH levels.
LH-releasing hormone Neg (not) Positive_regulation (-stimulated) of LH associated with clonidine
5) Confidence 0.27 Published 2004 Journal Fundam Clin Pharmacol Section Abstract Doc Link 15482372 Disease Relevance 0 Pain Relevance 0.19
The results show that CDP-choline can increase plasma ACTH and produce additional increases in serum levels of TSH, GH and LH stimulated by TRH, clonidine and LHRH, respectively.
LHRH Positive_regulation (stimulated) of LH in plasma associated with clonidine
6) Confidence 0.25 Published 2004 Journal Fundam Clin Pharmacol Section Abstract Doc Link 15482372 Disease Relevance 0 Pain Relevance 0.24
Little work has been done on the role of calcium in GnRH-induced luteinizing hormone (LH) release in species other than the rat.
GnRH Positive_regulation (induced) of LH
7) Confidence 0.17 Published 1988 Journal Am. J. Physiol. Section Abstract Doc Link 2845802 Disease Relevance 0 Pain Relevance 0.05
The neural influence is mediated for both LH and FSH by the decapeptide GnRH which is secreted into the hypophyseal portal vessels.
GnRH Positive_regulation (mediated) of LH in vessels
8) Confidence 0.13 Published 1983 Journal Clin Endocrinol Metab Section Abstract Doc Link 6323066 Disease Relevance 0 Pain Relevance 0

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox