INT298384

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Context Info
Confidence 0.77
First Reported 2010
Last Reported 2010
Negated 3
Speculated 0
Reported most in Body
Documents 1
Total Number 35
Disease Relevance 23.10
Pain Relevance 0.03

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (CYB5B) mitochondrion (CYB5B)
Anatomy Link Frequency
DEL 3
B cells 3
plasma 2
bone marrow 2
precursor cells 2
CYB5B (Homo sapiens)
Pain Link Frequency Relevance Heat
imagery 35 69.12 Quite High
member 8 35 26.36 Quite Low
Disease Link Frequency Relevance Heat
Hodgkin's Disease 2695 100.00 Very High Very High Very High
Lymphatic System Cancer 875 100.00 Very High Very High Very High
Toxicity 70 99.40 Very High Very High Very High
Anaplastic Large Cell Lymphoma 665 99.20 Very High Very High Very High
Diffuse Large B-cell Lymphoma 140 93.64 High High
Plasmacytoma 35 87.20 High High
Skin Diseases 35 86.56 High High
Precursor Cell Lymphoblastic Leukemia-lymphoma 35 86.44 High High
Lymphadenopathy 35 82.76 Quite High
Malignant Neoplastic Disease 35 81.96 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We noted, using this assay, that CYB5B expression is increased in HL cell lines KMH2 and L428, but not HDLM2, L1236, and L540.
Gene_expression (expression) of CYB5B associated with hodgkin's disease
1) Confidence 0.77 Published 2010 Journal Mol Cancer Section Body Doc Link PMC2829491 Disease Relevance 0.55 Pain Relevance 0
Gene expression of CYB5B was also measured in 5 HL cell lines, HDLM2, KMH2, L1236, L428, and L540, using Affymetrix GeneChip® Human Genome U133 Plus 2.0 Arrays.
Gene_expression (expression) of CYB5B associated with hodgkin's disease
2) Confidence 0.77 Published 2010 Journal Mol Cancer Section Body Doc Link PMC2829491 Disease Relevance 0.91 Pain Relevance 0
Jurkat cells were previously reported to have no surface expression of CYB5B protein by flow cytometry [24].
Neg (no) Gene_expression (expression) of CYB5B
3) Confidence 0.77 Published 2010 Journal Mol Cancer Section Body Doc Link PMC2829491 Disease Relevance 0.31 Pain Relevance 0
Again, there remains a possibility that reactive germinal centre B cells have increased expression of CYB5B, and this might lead to underestimation of relative mRNA levels in the cell lines tested.
Gene_expression (expression) of CYB5B in B cells
4) Confidence 0.77 Published 2010 Journal Mol Cancer Section Body Doc Link PMC2829491 Disease Relevance 0.61 Pain Relevance 0
We therefore used an additional platform to assess CYB5B gene expression levels in HL cell lines using the Affymetrix GeneChip® Human Genome U133 Plus 2.0 Arrays and used RNA from pooled benign germinal centre B cells isolated from reactive lymph nodes by microdissection as the calibrator.
Gene_expression (expression) of CYB5B in B cells associated with hodgkin's disease
5) Confidence 0.77 Published 2010 Journal Mol Cancer Section Body Doc Link PMC2829491 Disease Relevance 0.88 Pain Relevance 0
Surprisingly, ALCL cell line SR-786 showed no increase in CYB5B expression.
Gene_expression (expression) of CYB5B in SR-786 associated with anaplastic large cell lymphoma
6) Confidence 0.77 Published 2010 Journal Mol Cancer Section Body Doc Link PMC2829491 Disease Relevance 0.72 Pain Relevance 0
Affymetrix GeneChip® Human Genome U133 Plus 2.0 Arrays containing the CYB5B probe set 238554_at were used to assess the expression of CYB5B in HL cell lines in comparison to microdissected normal germinal centre B cells.
Gene_expression (expression) of CYB5B in B cells associated with hodgkin's disease
7) Confidence 0.77 Published 2010 Journal Mol Cancer Section Body Doc Link PMC2829491 Disease Relevance 0.10 Pain Relevance 0
When cases with both cytoplasmic staining and any intensity for membrane staining were included, 87% of all Classical types of HL were positive for CYB5B expression.
Gene_expression (expression) of CYB5B associated with hodgkin's disease
8) Confidence 0.77 Published 2010 Journal Mol Cancer Section Body Doc Link PMC2829491 Disease Relevance 0.81 Pain Relevance 0
Expression of CYB5B Protein in Reactive Lymph Nodes
Gene_expression (Expression) of CYB5B in Nodes
9) Confidence 0.77 Published 2010 Journal Mol Cancer Section Body Doc Link PMC2829491 Disease Relevance 0.69 Pain Relevance 0
The recombinant proteins encoded by clone RZPDp9028C1242 (full length CYB5B) and the clone RZPDp9028A0834 (expressing the COOH terminal region of CYB5B) (Figure 6B) were expressed and immunoblotted with both R23.1 and an anti-His antibody (Figure 6C).
Gene_expression (expressing) of CYB5B
10) Confidence 0.77 Published 2010 Journal Mol Cancer Section Body Doc Link PMC2829491 Disease Relevance 0.61 Pain Relevance 0
Quantitative PCR, using universal human reference RNA (UHRR; Stratagene) as the calibrator, showed CYB5B gene expression was increased in HL and NHL cell lines with the highest expression in ALCL line DEL, followed by HL lines L428 and KMH2.
Gene_expression (expression) of CYB5B in DEL associated with lymphatic system cancer, anaplastic large cell lymphoma and hodgkin's disease
11) Confidence 0.77 Published 2010 Journal Mol Cancer Section Body Doc Link PMC2829491 Disease Relevance 0.48 Pain Relevance 0
DM and HC performed the protein array identification of CYB5B, full length expression and Western blotting of recombinant CYB5B.
Gene_expression (expression) of CYB5B
12) Confidence 0.77 Published 2010 Journal Mol Cancer Section Body Doc Link PMC2829491 Disease Relevance 0.07 Pain Relevance 0
Sequencing of this clone revealed it expresses full length CYB5B.
Gene_expression (expresses) of CYB5B
13) Confidence 0.67 Published 2010 Journal Mol Cancer Section Body Doc Link PMC2829491 Disease Relevance 0.51 Pain Relevance 0
Sequencing of this clone revealed that it expresses full-length CYB5B.
Gene_expression (expresses) of CYB5B
14) Confidence 0.67 Published 2010 Journal Mol Cancer Section Body Doc Link PMC2829491 Disease Relevance 0.06 Pain Relevance 0
There was no evidence of overexpression of CYB5B mRNA in any of these samples.
Gene_expression (overexpression) of CYB5B
15) Confidence 0.67 Published 2010 Journal Mol Cancer Section Body Doc Link PMC2829491 Disease Relevance 0.57 Pain Relevance 0
Expression of CYB5B Protein in Reactive Lymph Nodes
Gene_expression (Expression) of CYB5B in Nodes
16) Confidence 0.67 Published 2010 Journal Mol Cancer Section Body Doc Link PMC2829491 Disease Relevance 0.69 Pain Relevance 0
Since we had previously reported that PHA-activated T cells do not express the 21 kDa protein at the cell surface [24], the detection of CYB5B in a PHA-induced T-lymphocyte cDNA library derived protein array may seem like a contradiction.
Gene_expression (detection) of CYB5B in T-lymphocyte
17) Confidence 0.67 Published 2010 Journal Mol Cancer Section Body Doc Link PMC2829491 Disease Relevance 0.05 Pain Relevance 0
This showed gains at the CYB5B locus at 16q22.1 in HL cell lines KMH2 and L428 (Figure 9), but not in ALCL cell lines DEL and SR786.


Gene_expression (locus) of CYB5B in DEL associated with anaplastic large cell lymphoma and hodgkin's disease
18) Confidence 0.67 Published 2010 Journal Mol Cancer Section Body Doc Link PMC2829491 Disease Relevance 1.38 Pain Relevance 0
DM and HC performed the protein array identification of CYB5B, full length expression and Western blotting of recombinant CYB5B.
Gene_expression (expression) of CYB5B
19) Confidence 0.60 Published 2010 Journal Mol Cancer Section Body Doc Link PMC2829491 Disease Relevance 0.07 Pain Relevance 0
CYB5B gene expression is increased in HL and NHL cell lines with the highest expression in ALCL line DEL, followed by HL lines L428 and KMH2.
Gene_expression (expression) of CYB5B in DEL associated with lymphatic system cancer, anaplastic large cell lymphoma and hodgkin's disease
20) Confidence 0.60 Published 2010 Journal Mol Cancer Section Body Doc Link PMC2829491 Disease Relevance 1.37 Pain Relevance 0

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