INT298386

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Context Info
Confidence 0.69
First Reported 2010
Last Reported 2010
Negated 2
Speculated 0
Reported most in Body
Documents 1
Total Number 6
Disease Relevance 4.41
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (CYB5B) mitochondrion (CYB5B)
Anatomy Link Frequency
B cell 1
SR-786 1
DEL cells 1
mononuclear cells 1
CYB5B (Homo sapiens)
Pain Link Frequency Relevance Heat
member 8 6 5.00 Very Low Very Low Very Low
imagery 6 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Anaplastic Large Cell Lymphoma 114 99.44 Very High Very High Very High
Hodgkin's Disease 462 99.36 Very High Very High Very High
Diffuse Large B-cell Lymphoma 24 96.12 Very High Very High Very High
Lymphatic System Cancer 150 91.20 High High
Plasmacytoma 6 48.64 Quite Low
Precursor Cell Lymphoblastic Leukemia-lymphoma 6 47.88 Quite Low
Malignant Neoplastic Disease 6 43.40 Quite Low
B-cell Lymphoma 12 39.44 Quite Low
Skin Diseases 6 31.32 Quite Low
Lymphadenopathy 6 27.52 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Thus the data from the Affymetrix experiments may be a true reflection of increased CYB5B mRNA in 2 of 5 HL cell lines with no bias created by the calibrator.
Positive_regulation (increased) of CYB5B associated with hodgkin's disease
1) Confidence 0.69 Published 2010 Journal Mol Cancer Section Body Doc Link PMC2829491 Disease Relevance 0.67 Pain Relevance 0
ALCL cell line SR-786 showed no increase in CYB5B mRNA in comparison to UHRR (Figure 7).
Neg (no) Positive_regulation (increase) of CYB5B in SR-786 associated with anaplastic large cell lymphoma
2) Confidence 0.69 Published 2010 Journal Mol Cancer Section Body Doc Link PMC2829491 Disease Relevance 0.91 Pain Relevance 0
RT-PCR assays of RNA extracted from T and B cell enriched fractions obtained from normal peripheral blood mononuclear cells, reactive lymph nodes, tonsils and normal bone marrow samples showed no evidence of increased mRNA levels of CYB5B in comparison to housekeeping gene GAPDH.


Positive_regulation (increased) of CYB5B in B cell
3) Confidence 0.46 Published 2010 Journal Mol Cancer Section Abstract Doc Link PMC2829491 Disease Relevance 1.25 Pain Relevance 0
CYB5B expression was detected by RT-PCR in the CD3+ enriched fractions and in the CD19+ enriched fractions from reactive lymph nodes, tonsils, peripheral blood mononuclear cells, and normal bone marrow samples, but at lower levels than housekeeping gene GAPDH (Figures 18 and 19), indicating no differential increase of CYB5B mRNA in benign lymphocytes even in reactive conditions.


Neg (no) Positive_regulation (increase) of CYB5B in mononuclear cells
4) Confidence 0.46 Published 2010 Journal Mol Cancer Section Body Doc Link PMC2829491 Disease Relevance 0.49 Pain Relevance 0
Thus, although gene amplification may be a mechanism of increased CYB5B mRNA levels in KMH2 and L428 cells, this is unlikely in DEL cells.
Positive_regulation (increased) of CYB5B in DEL cells
5) Confidence 0.46 Published 2010 Journal Mol Cancer Section Body Doc Link PMC2829491 Disease Relevance 0.52 Pain Relevance 0
There was no evidence of overexpression of CYB5B mRNA in any of these samples.
Positive_regulation (overexpression) of CYB5B
6) Confidence 0.46 Published 2010 Journal Mol Cancer Section Body Doc Link PMC2829491 Disease Relevance 0.57 Pain Relevance 0

General Comments

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