INT298387

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.69
First Reported 2010
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 1
Total Number 10
Disease Relevance 7.96
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (CYB5B) mitochondrion (CYB5B)
Anatomy Link Frequency
DEL 4
B cells 2
SR-786 2
mononuclear cells 2
CYB5B (Homo sapiens)
Pain Link Frequency Relevance Heat
member 8 10 5.00 Very Low Very Low Very Low
imagery 10 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Hodgkin's Disease 770 99.88 Very High Very High Very High
Lymphatic System Cancer 250 99.56 Very High Very High Very High
Anaplastic Large Cell Lymphoma 190 99.44 Very High Very High Very High
Plasmacytoma 10 70.52 Quite High
Precursor Cell Lymphoblastic Leukemia-lymphoma 10 69.76 Quite High
Toxicity 20 69.00 Quite High
Diffuse Large B-cell Lymphoma 40 67.56 Quite High
Malignant Neoplastic Disease 10 65.44 Quite High
Shock 10 52.00 Quite High
Skin Diseases 10 43.64 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Again, there remains a possibility that reactive germinal centre B cells have increased expression of CYB5B, and this might lead to underestimation of relative mRNA levels in the cell lines tested.
Positive_regulation (increased) of Gene_expression (expression) of CYB5B in B cells
1) Confidence 0.69 Published 2010 Journal Mol Cancer Section Body Doc Link PMC2829491 Disease Relevance 0.62 Pain Relevance 0
When cases with both cytoplasmic staining and any intensity for membrane staining were included, 87% of all Classical types of HL were positive for CYB5B expression.
Positive_regulation (positive) of Gene_expression (expression) of CYB5B associated with hodgkin's disease
2) Confidence 0.69 Published 2010 Journal Mol Cancer Section Body Doc Link PMC2829491 Disease Relevance 0.82 Pain Relevance 0
We noted, using this assay, that CYB5B expression is increased in HL cell lines KMH2 and L428, but not HDLM2, L1236, and L540.
Positive_regulation (increased) of Gene_expression (expression) of CYB5B associated with hodgkin's disease
3) Confidence 0.69 Published 2010 Journal Mol Cancer Section Body Doc Link PMC2829491 Disease Relevance 0.55 Pain Relevance 0
Quantitative PCR, using universal human reference RNA (UHRR; Stratagene) as the calibrator, showed CYB5B gene expression was increased in HL and NHL cell lines with the highest expression in ALCL line DEL, followed by HL lines L428 and KMH2.
Positive_regulation (increased) of Gene_expression (expression) of CYB5B in DEL associated with lymphatic system cancer, anaplastic large cell lymphoma and hodgkin's disease
4) Confidence 0.69 Published 2010 Journal Mol Cancer Section Body Doc Link PMC2829491 Disease Relevance 0.53 Pain Relevance 0
Surprisingly, ALCL cell line SR-786 showed no increase in CYB5B expression.
Neg (no) Positive_regulation (increase) of Gene_expression (expression) of CYB5B in SR-786 associated with anaplastic large cell lymphoma
5) Confidence 0.69 Published 2010 Journal Mol Cancer Section Body Doc Link PMC2829491 Disease Relevance 0.72 Pain Relevance 0
There was no evidence of overexpression of CYB5B mRNA in any of these samples.
Positive_regulation (overexpression) of Gene_expression (overexpression) of CYB5B
6) Confidence 0.50 Published 2010 Journal Mol Cancer Section Body Doc Link PMC2829491 Disease Relevance 0.57 Pain Relevance 0
CYB5B expression was detected by RT-PCR in the CD3+ enriched fractions and in the CD19+ enriched fractions from reactive lymph nodes, tonsils, peripheral blood mononuclear cells, and normal bone marrow samples, but at lower levels than housekeeping gene GAPDH (Figures 18 and 19), indicating no differential increase of CYB5B mRNA in benign lymphocytes even in reactive conditions.


Positive_regulation (detected) of Gene_expression (expression) of CYB5B in mononuclear cells
7) Confidence 0.46 Published 2010 Journal Mol Cancer Section Body Doc Link PMC2829491 Disease Relevance 0.40 Pain Relevance 0
CYB5B gene expression is increased in a subset of HL and NHL cell lines tested.
Positive_regulation (increased) of Gene_expression (expression) of CYB5B associated with lymphatic system cancer and hodgkin's disease
8) Confidence 0.46 Published 2010 Journal Mol Cancer Section Abstract Doc Link PMC2829491 Disease Relevance 1.29 Pain Relevance 0
CYB5B gene expression is increased in HL and NHL cell lines with the highest expression in ALCL line DEL, followed by HL lines L428 and KMH2.
Positive_regulation (increased) of Gene_expression (expression) of CYB5B in DEL associated with lymphatic system cancer, anaplastic large cell lymphoma and hodgkin's disease
9) Confidence 0.46 Published 2010 Journal Mol Cancer Section Body Doc Link PMC2829491 Disease Relevance 1.37 Pain Relevance 0
Quantitative PCR showed CYB5B gene expression was increased in HL and NHL cell lines.
Positive_regulation (increased) of Gene_expression (expression) of CYB5B associated with lymphatic system cancer and hodgkin's disease
10) Confidence 0.46 Published 2010 Journal Mol Cancer Section Abstract Doc Link PMC2829491 Disease Relevance 1.08 Pain Relevance 0

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox