INT298390

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Context Info
Confidence 0.69
First Reported 2010
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 1
Total Number 3
Disease Relevance 2.58
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (CYB5B) mitochondrion (CYB5B)
Anatomy Link Frequency
DEL 2
lymphocytes 2
DEL cells 2
CYB5B (Homo sapiens)
Pain Link Frequency Relevance Heat
member 8 3 5.00 Very Low Very Low Very Low
imagery 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Anaplastic Large Cell Lymphoma 57 99.36 Very High Very High Very High
Hodgkin's Disease 231 99.08 Very High Very High Very High
Lymphatic System Cancer 75 91.96 High High
Toxicity 6 59.04 Quite High
Shock 3 42.04 Quite Low
Plasmacytoma 3 37.00 Quite Low
Precursor Cell Lymphoblastic Leukemia-lymphoma 3 36.24 Quite Low
Diffuse Large B-cell Lymphoma 12 34.04 Quite Low
Malignant Neoplastic Disease 3 31.76 Quite Low
Cancer 12 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Thus, although gene amplification may be a mechanism of increased CYB5B mRNA levels in KMH2 and L428 cells, this is unlikely in DEL cells.
Positive_regulation (increased) of Transcription (levels) of CYB5B in DEL cells
1) Confidence 0.69 Published 2010 Journal Mol Cancer Section Body Doc Link PMC2829491 Disease Relevance 0.52 Pain Relevance 0
Since there was evidence that HL cell lines KMH2 and L428 consistently showed increased expression of CYB5B mRNA regardless of the assay method used, and ALCL cell line DEL also showed an increase at even higher levels than the 2 HL cell lines, one of the possible explanations was amplification of the CYB5B gene in these cell lines.
Positive_regulation (increased) of Transcription (expression) of CYB5B in DEL associated with anaplastic large cell lymphoma and hodgkin's disease
2) Confidence 0.69 Published 2010 Journal Mol Cancer Section Body Doc Link PMC2829491 Disease Relevance 0.71 Pain Relevance 0
CYB5B mRNA expression is not increased in reactive lymphocytes but the CYB5B protein is present in detectable quantities in the cytoplasm of such cells.
Neg (not) Positive_regulation (increased) of Transcription (expression) of CYB5B in lymphocytes
3) Confidence 0.46 Published 2010 Journal Mol Cancer Section Body Doc Link PMC2829491 Disease Relevance 1.34 Pain Relevance 0

General Comments

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