INT298395

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Context Info
Confidence 0.71
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 9
Disease Relevance 7.33
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (CYB5B) mitochondrion (CYB5B)
Anatomy Link Frequency
SR-786 2
lymph nodes 1
DEL 1
B cells 1
lymphocytes 1
CYB5B (Homo sapiens)
Pain Link Frequency Relevance Heat
member 8 9 5.00 Very Low Very Low Very Low
imagery 9 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Anaplastic Large Cell Lymphoma 171 99.36 Very High Very High Very High
Hodgkin's Disease 693 98.88 Very High Very High Very High
Plasmacytoma 9 96.16 Very High Very High Very High
Precursor Cell Lymphoblastic Leukemia-lymphoma 9 95.40 Very High Very High Very High
Diffuse Large B-cell Lymphoma 36 93.20 High High
Lymphatic System Cancer 225 91.96 High High
Malignant Neoplastic Disease 9 90.92 High High
Toxicity 18 59.04 Quite High
Shock 9 42.04 Quite Low
B-cell Lymphoma 18 21.20 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We next looked at the relative expression of CYB5B mRNA in cell lines.
Transcription (expression) of CYB5B
1) Confidence 0.71 Published 2010 Journal Mol Cancer Section Body Doc Link PMC2829491 Disease Relevance 0.42 Pain Relevance 0
We then looked at CYB5B mRNA in fresh samples of normal T and B cells harvested from peripheral blood, reactive lymph nodes, tonsils, and normal bone marrow samples using GAPDH, an ubiquitous housekeeping gene, as the calibrator.
Transcription (at) of CYB5B in lymph nodes
2) Confidence 0.71 Published 2010 Journal Mol Cancer Section Body Doc Link PMC2829491 Disease Relevance 0.65 Pain Relevance 0
Since there was evidence that HL cell lines KMH2 and L428 consistently showed increased expression of CYB5B mRNA regardless of the assay method used, and ALCL cell line DEL also showed an increase at even higher levels than the 2 HL cell lines, one of the possible explanations was amplification of the CYB5B gene in these cell lines.
Transcription (expression) of CYB5B in DEL associated with anaplastic large cell lymphoma and hodgkin's disease
3) Confidence 0.71 Published 2010 Journal Mol Cancer Section Body Doc Link PMC2829491 Disease Relevance 0.71 Pain Relevance 0
Thus, although gene amplification may be a mechanism of increased CYB5B mRNA levels in KMH2 and L428 cells, this is unlikely in DEL cells.
Transcription (levels) of CYB5B in DEL cells
4) Confidence 0.71 Published 2010 Journal Mol Cancer Section Body Doc Link PMC2829491 Disease Relevance 0.52 Pain Relevance 0
Two HL cell lines (KMH2 and L428) had higher expression levels than benign germinal centre B cells, whereas the others (HDLM2, L1236, and L540) had similar or lower expression of CYB5B mRNA compared to germinal centre B cells (Figure 8).


Transcription (expression) of CYB5B in B cells associated with hodgkin's disease
5) Confidence 0.71 Published 2010 Journal Mol Cancer Section Body Doc Link PMC2829491 Disease Relevance 1.29 Pain Relevance 0
It is possible therefore that UHRR contains a relatively high concentration of CYB5B mRNA and, if used as the calibrator, may lead to an underestimation of CYB5B in cell lines such as SR-786 if it has similar levels of the CYB5B mRNA.
Transcription (levels) of CYB5B in SR-786
6) Confidence 0.69 Published 2010 Journal Mol Cancer Section Body Doc Link PMC2829491 Disease Relevance 0.89 Pain Relevance 0
It is possible therefore that UHRR contains a relatively high concentration of CYB5B mRNA and, if used as the calibrator, may lead to an underestimation of CYB5B in cell lines such as SR-786 if it has similar levels of the CYB5B mRNA.
Transcription (concentration) of CYB5B in SR-786
7) Confidence 0.53 Published 2010 Journal Mol Cancer Section Body Doc Link PMC2829491 Disease Relevance 0.86 Pain Relevance 0
CYB5B mRNA expression is not increased in reactive lymphocytes but the CYB5B protein is present in detectable quantities in the cytoplasm of such cells.
Transcription (expression) of CYB5B in lymphocytes
8) Confidence 0.53 Published 2010 Journal Mol Cancer Section Body Doc Link PMC2829491 Disease Relevance 1.34 Pain Relevance 0
We then looked at CYB5B mRNA in fresh samples of normal T and B cells harvested from peripheral blood, reactive lymph nodes, tonsils, and normal bone marrow samples using GAPDH, an ubiquitous housekeeping gene, as the calibrator.
Transcription (at) of CYB5B in tonsils
9) Confidence 0.24 Published 2010 Journal Mol Cancer Section Body Doc Link PMC2829491 Disease Relevance 0.65 Pain Relevance 0

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