INT298415

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Context Info
Confidence 0.61
First Reported 2010
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 2
Total Number 7
Disease Relevance 7.78
Pain Relevance 0.11

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (ATF3) nucleolus (ATF3) nucleus (ATF3)
Anatomy Link Frequency
colon 6
ATF3 (Homo sapiens)
Pain Link Frequency Relevance Heat
cINOD 18 73.68 Quite High
COX-2 inhibitor 12 71.28 Quite High
Inflammation 4 30.56 Quite Low
cytokine 8 5.00 Very Low Very Low Very Low
antagonist 6 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Colon Cancer 307 100.00 Very High Very High Very High
Cancer 490 99.84 Very High Very High Very High
Metastasis 84 99.84 Very High Very High Very High
Reprotox - General 1 6 98.88 Very High Very High Very High
Carcinoma 30 96.28 Very High Very High Very High
Lung Cancer 59 95.80 Very High Very High Very High
Apoptosis 55 93.76 High High
Skin Cancer 7 92.60 High High
Hyperplasia 6 90.48 High High
Pressure And Volume Under Development 12 89.92 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Inhibition of SAPK (SP600125) most robustly up-regulated ATF3 mRNA expression (Figure 2A).
Regulation (regulated) of Gene_expression (expression) of ATF3 mRNA
1) Confidence 0.61 Published 2010 Journal BMC Cancer Section Body Doc Link PMC3003660 Disease Relevance 0.64 Pain Relevance 0
We conclude from these experiments that ATF3 expression in colon cancer cells is complexly controlled through the interaction of multiple molecular signaling pathways.
Regulation (controlled) of Gene_expression (expression) of ATF3 in colon associated with colon cancer
2) Confidence 0.61 Published 2010 Journal BMC Cancer Section Body Doc Link PMC3003660 Disease Relevance 0.80 Pain Relevance 0
We next tested the effects of inhibited ATF3 expression on tumor metastasis in vivo in a model of hepatic tumor growth and in a model of peritoneal carcinomatosis.
Regulation (effects) of Gene_expression (expression) of ATF3 associated with cancer, carcinoma and metastasis
3) Confidence 0.61 Published 2010 Journal BMC Cancer Section Body Doc Link PMC3003660 Disease Relevance 1.50 Pain Relevance 0
The effects of diminished ATF3 expression on tumor growth in vivo were first investigated in a subcutaneous tumor model using HCT116 cells.
Spec (investigated) Regulation (effects) of Gene_expression (expression) of ATF3 associated with cancer
4) Confidence 0.61 Published 2010 Journal BMC Cancer Section Body Doc Link PMC3003660 Disease Relevance 1.11 Pain Relevance 0
In colon cancer, the effects of ATF3 expression are particularly perplexing.
Regulation (effects) of Gene_expression (expression) of ATF3 in colon associated with colon cancer
5) Confidence 0.61 Published 2010 Journal BMC Cancer Section Body Doc Link PMC3003660 Disease Relevance 1.57 Pain Relevance 0.11
Since studies report conflicting results regarding the role and expression of ATF3 in colorectal cancers, we determined ATF3 mRNA expression in human colon cancer specimens.
Regulation (regarding) of Gene_expression (expression) of ATF3 in colon associated with colon cancer
6) Confidence 0.45 Published 2010 Journal BMC Cancer Section Body Doc Link PMC3003660 Disease Relevance 1.69 Pain Relevance 0
g/ml Onconase showed remarkably consistent up-regulated expression of IL-24 as well as of ATF3 and IL-6 (Figure 4A).
Regulation (regulated) of Gene_expression (expression) of ATF3
7) Confidence 0.40 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2829496 Disease Relevance 0.48 Pain Relevance 0

General Comments

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