INT298428

Context Info Confidence 0.26 First Reported 2010 Last Reported 2010 Negated 0 Speculated 1 Reported most in Body Documents 1 Total Number 1 Disease Relevance 1.55 Pain Relevance 0.26

endosome (PRF1) extracellular region (PRF1) cytoplasmic membrane-bounded vesicle (PRF1) plasma membrane (PRF1)

PRF1 (Homo sapiens)

Pain Link Frequency Relevance Heat drug abuse 1 80.44 depression 1 79.76 headache 1 74.28 Pain 1 71.88 cytokine 10 67.12 chemokine 12 5.00 Inflammatory response 1 5.00 rheumatoid arthritis 1 5.00

Disease Link Frequency Relevance Heat Chronic Fatigue Syndrome 78 96.60 Appetite Loss 1 82.44 Psychosis 1 81.60 Manic Depressive Disorder 1 81.16 Polycystic Ovary Syndrome 1 81.04 Drug Dependence 1 80.44 Depression 2 79.76 Headache 1 74.28 Pressure And Volume Under Development 1 73.12 Pain 1 71.88

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Some studies have suggested that these decreases in NK function may involve low levels of granzymes, perforin proteins and increases in the expression of the granzyme gene GZMA [6,8].

Spec (may) Regulation (involve) of Positive_regulation (increases) of perforin

1) Confidence 0.26 Published 2010 Journal J Transl Med Section Body Doc Link PMC2829521 Disease Relevance 1.55 Pain Relevance 0.26

General Comments

This test has worked.