INT298433

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Context Info
Confidence 0.07
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.62
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytoplasm (CDH1, SNAI1, CDH1) endosome (CDH1, CDH1) cell adhesion (CDH1, CDH1)
Golgi apparatus (CDH1, CDH1) plasma membrane (CDH1, CDH1) nucleus (SNAI1)
CDH1 (Homo sapiens)
SNAI1 (Homo sapiens)
CDH1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 2 5.00 Very Low Very Low Very Low
palliative 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Repression 2 100.00 Very High Very High Very High
Cancer 95 91.04 High High
Adhesions 4 83.84 Quite High
Skin Cancer 20 77.44 Quite High
Carcinoma 3 52.32 Quite High
Malignant Neoplastic Disease 2 35.04 Quite Low
Metastasis 30 31.84 Quite Low
Recurrence 4 5.00 Very Low Very Low Very Low
Disease 2 5.00 Very Low Very Low Very Low
INFLAMMATION 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Binding of SNAI1 to E-box elements in the E-cadherin promoter region leads to transcriptional repression of the CDH1 gene and resulting loss of E-cadherin expression, which is considered a "hallmark" of EMT.
E-cadherin Binding (Binding) of SNAI1 Negative_regulation (loss) of Gene_expression (expression) of E-cadherin associated with repression
1) Confidence 0.07 Published 2010 Journal BMC Clin Pathol Section Body Doc Link PMC2829523 Disease Relevance 0.62 Pain Relevance 0

General Comments

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