INT298438

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Context Info
Confidence 0.14
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 1.16
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytoplasm (CDH1, SNAI1) endosome (CDH1) cell adhesion (CDH1)
Golgi apparatus (CDH1) nucleus (SNAI1) intracellular (SNAI1)
CDH1 (Homo sapiens)
SNAI1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 4 12.52 Low Low
palliative 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Repression 4 98.32 Very High Very High Very High
Cancer 190 92.48 High High
Adhesions 8 74.80 Quite High
Skin Cancer 40 68.40 Quite High
Metastasis 60 67.04 Quite High
Carcinoma 6 51.28 Quite High
Malignant Neoplastic Disease 4 35.04 Quite Low
INFLAMMATION 4 12.52 Low Low
Recurrence 8 5.00 Very Low Very Low Very Low
Disease 4 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Binding of SNAI1 to E-box elements in the E-cadherin promoter region leads to transcriptional repression of the CDH1 gene and resulting loss of E-cadherin expression, which is considered a "hallmark" of EMT.
E-cadherin Binding (Binding) of SNAI1 associated with repression
1) Confidence 0.14 Published 2010 Journal BMC Clin Pathol Section Body Doc Link PMC2829523 Disease Relevance 0.53 Pain Relevance 0
As in several previous studies (Additional file 6), SNAI1 expression in our cohort was not significantly associated with E-cadherin loss.
E-cadherin Binding (associated) of SNAI1
2) Confidence 0.14 Published 2010 Journal BMC Clin Pathol Section Body Doc Link PMC2829523 Disease Relevance 0.63 Pain Relevance 0

General Comments

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