INT298456

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Context Info
Confidence 0.00
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 1.86
Pain Relevance 2.85

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (Prkaca, Adarb1) nucleus (Prkaca, Adarb1) mitochondrion (Prkaca)
Golgi apparatus (Prkaca) intracellular (Adarb1) protein complex (Prkaca)
Anatomy Link Frequency
amygdala 2
Prkaca (Rattus norvegicus)
Adarb1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Pain 98 100.00 Very High Very High Very High
nMDA receptor 38 100.00 Very High Very High Very High
Spinal cord 10 99.68 Very High Very High Very High
amygdala 174 97.44 Very High Very High Very High
Neuronal excitability 18 96.96 Very High Very High Very High
Calcitonin gene-related peptide 206 95.32 Very High Very High Very High
nMDA receptor antagonist 12 91.28 High High
withdrawal 20 84.84 Quite High
painful pain 2 83.68 Quite High
depression 2 73.48 Quite High
Disease Link Frequency Relevance Heat
Pain 96 100.00 Very High Very High Very High
Nociception 8 100.00 Very High Very High Very High
Injury 14 82.00 Quite High
Depression 2 73.48 Quite High
Anxiety Disorder 2 72.88 Quite High
Affective Disorder 2 72.24 Quite High
Neuropathic Pain 6 64.40 Quite High
INFLAMMATION 2 63.56 Quite High
Temporomandibular Joint Disorders 2 45.68 Quite Low
Disease 2 43.96 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
PKA increases synaptic transmission in the nociceptive parabrachio-amygdaloid pathway through phosphorylation of NMDA receptors [26].
PKA Positive_regulation (increases) of Phosphorylation (phosphorylation) of receptors associated with nociception and nmda receptor
1) Confidence 0.00 Published 2010 Journal Mol Pain Section Body Doc Link PMC2829526 Disease Relevance 1.44 Pain Relevance 1.66
Both PKA and PKC contribute to pain-related phosphorylation of NMDA receptors in the spinal cord [63,64] whereas only PKA is involved in the amygdala [26,34].
PKA Positive_regulation (contribute) of Phosphorylation (phosphorylation) of receptors in amygdala associated with pain, nmda receptor, amygdala and spinal cord
2) Confidence 0.00 Published 2010 Journal Mol Pain Section Body Doc Link PMC2829526 Disease Relevance 0.41 Pain Relevance 1.19

General Comments

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