INT29846

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Context Info
Confidence 0.55
First Reported 1988
Last Reported 2003
Negated 0
Speculated 0
Reported most in Abstract
Documents 3
Total Number 6
Disease Relevance 1.94
Pain Relevance 0.78

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

molecular_function (Lpo) cellular_component (Lpo) biological_process (Lpo)
Lpo (Mus musculus)
Pain Link Frequency Relevance Heat
alcohol 3 99.04 Very High Very High Very High
Paracetamol 9 93.04 High High
Glutamate 1 72.84 Quite High
Nicotine 4 9.44 Low Low
anesthesia 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Injury 7 99.80 Very High Very High Very High
Stress 58 98.24 Very High Very High Very High
Hepatotoxicity 4 97.72 Very High Very High Very High
Nicotine Addiction 20 96.60 Very High Very High Very High
Nephrotoxicity 4 89.12 High High
Overdose 1 75.00 Quite High
Necrosis 1 64.04 Quite High
Disease 20 45.12 Quite Low
Cancer 8 44.40 Quite Low
Genetic Predisposition To Disease 4 21.84 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In the sham exposed mice fed with AT for 4, 6 and 8 weeks, there was a significant decrease in the LPO levels observed as compared to their control counter parts.
Negative_regulation (decrease) of LPO
1) Confidence 0.55 Published 2001 Journal BMC Biochem Section Body Doc Link PMC60661 Disease Relevance 0.24 Pain Relevance 0
There was a marked decrease observed in the LPO levels in the animals treated with AT alone for 4, 6, or 8 weeks, when compared to their control counterparts.
Negative_regulation (decrease) of LPO
2) Confidence 0.41 Published 2001 Journal BMC Biochem Section Abstract Doc Link PMC60661 Disease Relevance 0.10 Pain Relevance 0
On the other hand, in this group, LPO levels decreased indicating the antioxidant role of GSH in combating the oxidative stress.
Negative_regulation (decreased) of LPO associated with stress
3) Confidence 0.41 Published 2001 Journal BMC Biochem Section Body Doc Link PMC60661 Disease Relevance 0.29 Pain Relevance 0
LPO levels also showed a significant decline from 16.53 ± 0.81 to 13.96 ± 0.70 nmoles MDA mg protein-1 30 min-1 when mice were treated with AT (5 I.U.
Negative_regulation (decline) of LPO
4) Confidence 0.41 Published 2001 Journal BMC Biochem Section Body Doc Link PMC60661 Disease Relevance 0.05 Pain Relevance 0
Both treatments reduced LPO and injury after allyl alcohol but had no effect on AAP hepatotoxicity.
Negative_regulation (reduced) of LPO associated with injury, hepatotoxicity and alcohol
5) Confidence 0.35 Published 2003 Journal Toxicol. Sci. Section Abstract Doc Link 12944590 Disease Relevance 0.79 Pain Relevance 0.21
Diethyldithiocarbamate (DTC, 200 mg/kg i.p.) or deferrioxamine (DFO, 500 mg/kg i.p.) both given 30 min before PA, inhibited in vivo LPO.
Negative_regulation (inhibited) of LPO
6) Confidence 0.32 Published 1988 Journal J Appl Toxicol Section Abstract Doc Link 2846674 Disease Relevance 0.48 Pain Relevance 0.57

General Comments

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