INT298476

Context Info Confidence 0.01 First Reported 2010 Last Reported 2010 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 1 Disease Relevance 0.33 Pain Relevance 0.12

plasma membrane (CD40LG, HLA-DRB1) endosome (HLA-DRB1) extracellular space (CD40LG) extracellular region (CD40LG) Golgi apparatus (HLA-DRB1) endoplasmic reticulum (HLA-DRB1)

Anatomy Link Frequency T cells 1 CD40LG (Homo sapiens) HLA-DRB1 (Homo sapiens)

Pain Link Frequency Relevance Heat Multiple sclerosis 82 98.24 cytokine 9 57.76 chemokine 35 38.84 Inflammation 38 5.00 5HT 23 5.00 metalloproteinase 15 5.00 agonist 10 5.00 aspirin 5 5.00 sSRI 5 5.00 Serotonin 4 5.00

Disease Link Frequency Relevance Heat Multiple Sclerosis 93 98.24 Cardiovascular Disease 3 83.68 Coagulation Disorder 3 56.96 Wound Healing 1 31.80 Vasculitis 5 22.92 INFLAMMATION 40 5.00 Disease 30 5.00 Neurodegenerative Disease 8 5.00 Thrombosis 6 5.00 Thrombocytopenia 5 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Harp et al demonstrated that CD40L/IL-4 as well as another stimulating reagent induced B cells to upregulate CD80 and HLA-DR; however, only CD40L/IL-4 was effective in eliciting CNS-antigen specific proliferation by autologous T cells [109].

CD40L Positive_regulation (upregulate) of HLA-DR in T cells

1) Confidence 0.01 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC2829540 Disease Relevance 0.33 Pain Relevance 0.12

General Comments

This test has worked.