INT29853

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Context Info
Confidence 0.53
First Reported 1988
Last Reported 1994
Negated 0
Speculated 0
Reported most in Abstract
Documents 3
Total Number 3
Disease Relevance 0.09
Pain Relevance 1.31

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
brain 1
Srms (Rattus norvegicus)
Pain Link Frequency Relevance Heat
opiate 4 100.00 Very High Very High Very High
Spinal cord 1 98.92 Very High Very High Very High
Hippocampus 2 96.28 Very High Very High Very High
Substantia nigra 1 92.68 High High
Pyramidal cell 1 91.52 High High
Central grey 1 89.56 High High
Serotonin 2 86.24 High High
antagonist 2 81.80 Quite High
fortral 1 80.76 Quite High
fluoxetine 2 79.04 Quite High
Disease Link Frequency Relevance Heat
Urological Neuroanatomy 1 89.56 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The present results suggest that cerebral serotonergic transmission may play a role in the regulation of cerebral sigma binding sites in the rat.
Regulation (regulation) of sites
1) Confidence 0.53 Published 1993 Journal Eur. J. Pharmacol. Section Abstract Doc Link 8359206 Disease Relevance 0 Pain Relevance 0.41
This regionally specific modulation of opiate binding sites suggests that, for each receptor type, the level of tonic activation varies between individual brain areas.
Regulation (modulation) of sites in brain associated with opiate
2) Confidence 0.11 Published 1988 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 2846828 Disease Relevance 0.09 Pain Relevance 0.82
The pharmacological profile of [3H]SR 31747 binding sites was consistent with the presence of specific sites distinct from classical sigma 1 and sigma 2 receptor subtypes strongly suggesting an allosteric modulation of sigma sites by SR 31747.
Regulation (modulation) of sites
3) Confidence 0.03 Published 1994 Journal J. Neuroimmunol. Section Abstract Doc Link 7794416 Disease Relevance 0 Pain Relevance 0.08

General Comments

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