INT298539

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Context Info
Confidence 0.39
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 3
Disease Relevance 0.95
Pain Relevance 0.48

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Golgi apparatus (CAV2) mitochondrion organization (CAV2) intracellular (CAV2)
protein complex (CAV2) cytoplasm (CAV2) cytosol (CAV2)
CAV2 (Homo sapiens)
Pain Link Frequency Relevance Heat
vincristine 96 100.00 Very High Very High Very High
Calcium channel 15 50.00 Quite Low
Pain 3 5.00 Very Low Very Low Very Low
palliative 2 5.00 Very Low Very Low Very Low
addiction 1 5.00 Very Low Very Low Very Low
Neurotransmitter 1 5.00 Very Low Very Low Very Low
Opioid 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Thrombocytopenia 12 98.68 Very High Very High Very High
Neutropenia 12 98.68 Very High Very High Very High
Lung Cancer 20 96.96 Very High Very High Very High
Toxicity 12 84.04 Quite High
Small Cell Lung Cancer 60 41.04 Quite Low
Disease 36 5.00 Very Low Very Low Very Low
Recurrence 34 5.00 Very Low Very Low Very Low
Metastasis 22 5.00 Very Low Very Low Very Low
Cancer 8 5.00 Very Low Very Low Very Low
Pain 3 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Agler and colleagues [25] reported that the N-terminus of Cav2.2 is capable of interacting with the domain I-II linker, and that this interaction contributes to G protein inhibition of the channel.
Cav2 Binding (interacting) of
1) Confidence 0.39 Published 2010 Journal Mol Brain Section Body Doc Link PMC2829547 Disease Relevance 0 Pain Relevance 0
CAV was associated with significantly less grade 4 thrombocytopenia compared with IV topotecan (risk ratio = 5.83; 95% CI, 2.35 to 14.42).
CAV Binding (associated) of associated with vincristine and thrombocytopenia
2) Confidence 0.12 Published 2010 Journal BMC Cancer Section Abstract Doc Link PMC2931489 Disease Relevance 0.33 Pain Relevance 0.20
The indirect comparisons, using Bucher's method, showed that CAV was associated with significantly more grade 4 neutropenia compared with oral topotecan; while oral topotecan was associated with significantly more grade 4 thrombocytopenia compared with CAV.


CAV Binding (associated) of associated with neutropenia, vincristine and thrombocytopenia
3) Confidence 0.12 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2931489 Disease Relevance 0.62 Pain Relevance 0.28

General Comments

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