INT29854

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Context Info
Confidence 0.20
First Reported 1988
Last Reported 1988
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 2
Disease Relevance 0.07
Pain Relevance 1.53

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
brain 4
Srms (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Enkephalin 6 100.00 Very High Very High Very High
Opioid 2 100.00 Very High Very High Very High
narcan 8 99.58 Very High Very High Very High
antagonist 4 94.28 High High
agonist 2 93.44 High High
opiate 8 93.08 High High
opioid receptor 2 75.00 Quite High
Central grey 2 73.76 Quite High
Pyramidal cell 2 69.44 Quite High
Substantia nigra 2 67.28 Quite High
Disease Link Frequency Relevance Heat
Urological Neuroanatomy 2 73.76 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The binding of [3H]-D-Ala2MePhe4Glyol enkephalin (3H-DAGO) to mu opioid sites was increased in many brain regions after chronic administration (7 days) of a low dose of naloxone (0.5 mg/kg/hr).
Positive_regulation (increased) of sites Binding (binding) of in brain associated with narcan, enkephalin and opioid
1) Confidence 0.20 Published 1988 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 2846828 Disease Relevance 0 Pain Relevance 0.65
In contrast, after administration of a higher dose of naloxone (3.0 mg/kg/hr), the binding to mu, delta and kappa sites was increased in many brain areas, suggesting that up-regulation is observed only when a sufficient proportion of the receptors in vivo are occupied by the antagonist.
Positive_regulation (increased) of sites Binding (binding) of in brain associated with antagonist and narcan
2) Confidence 0.20 Published 1988 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 2846828 Disease Relevance 0.07 Pain Relevance 0.88

General Comments

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