INT298546

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Context Info
Confidence 0.18
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 3
Disease Relevance 0.70
Pain Relevance 0.71

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
macrophages 1
eye 1
microglia 1
Ocm (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Inflammation 33 93.24 High High
halothane 6 82.40 Quite High
Analgesic 3 68.80 Quite High
Buprenorphine 3 67.92 Quite High
Thalamus 36 62.48 Quite High
Spinal cord 51 59.44 Quite High
Inflammatory response 18 50.44 Quite High
dorsal root ganglion 12 5.00 Very Low Very Low Very Low
Peripheral nerve injury 9 5.00 Very Low Very Low Very Low
projection neuron 6 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Ganglion Cysts 18 98.60 Very High Very High Very High
INFLAMMATION 51 93.24 High High
Stab Wounds 12 63.60 Quite High
Spinal Cord Injury 12 59.44 Quite High
Injury 33 28.48 Quite Low
Nervous System Injury 18 27.36 Quite Low
Death 24 5.00 Very Low Very Low Very Low
Overdose 3 5.00 Very Low Very Low Very Low
Apoptosis 3 5.00 Very Low Very Low Very Low
Vibrio Infection 3 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
It has been suggested that macrophages in the eye secrete oncomodulin, which in turn stimulates retinal ganglion cells to regenerate their axons [54].
Localization (secrete) of oncomodulin in eye associated with ganglion cysts
1) Confidence 0.18 Published 2010 Journal BMC Neurosci Section Body Doc Link PMC2829570 Disease Relevance 0.36 Pain Relevance 0.13
The molecular changes in such microglia are unknown but evidence from the visual system suggests that activated microglia/macrophages may be capable of stimulating axonal regeneration [20,56,67], possibly by the secretion of oncomodulin [54].


Localization (secretion) of oncomodulin in microglia
2) Confidence 0.16 Published 2010 Journal BMC Neurosci Section Body Doc Link PMC2829570 Disease Relevance 0.17 Pain Relevance 0.29
The molecular changes in such microglia are unknown but evidence from the visual system suggests that activated microglia/macrophages may be capable of stimulating axonal regeneration [20,56,67], possibly by the secretion of oncomodulin [54].


Localization (secretion) of oncomodulin in macrophages
3) Confidence 0.05 Published 2010 Journal BMC Neurosci Section Body Doc Link PMC2829570 Disease Relevance 0.17 Pain Relevance 0.29

General Comments

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