INT298583

Context Info Confidence 0.04 First Reported 2009 Last Reported 2009 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 2 Disease Relevance 0.10 Pain Relevance 0

signal transduction (TNFRSF11B) extracellular region (TNFRSF11B) proteinaceous extracellular matrix (TNFRSF11B) plasma membrane (PTGER2) extracellular matrix organization (TNFRSF11B) signal transducer activity (PTGER2)

Anatomy Link Frequency chondrocytes 2 PTGER2 (Homo sapiens) TNFRSF11B (Homo sapiens)

Pain Link Frequency Relevance Heat Snapping jaw 16 5.00 cytokine 12 5.00 Inflammation 12 5.00 Pain 4 5.00 metalloproteinase 2 5.00 Hyperalgesia 2 5.00 Osteoarthritis 2 5.00

Disease Link Frequency Relevance Heat Targeted Disruption 2 95.40 Temporomandibular Joint Syndrome 16 5.00 INFLAMMATION 12 5.00 Arthropathy 8 5.00 Pain 4 5.00 Hypercalcemia 4 5.00 Hyperalgesia 2 5.00 Osteoporosis 2 5.00 Osteoarthritis 2 5.00 Milium 2 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Considering our results, these findings suggest that the effect of PGE2 on OPG expression may differ according to cell type.

PGE2 Regulation (effect) of Gene_expression (expression) of OPG

1) Confidence 0.04 Published 2009 Journal Mediators of Inflammation Section Body Doc Link PMC2829618 Disease Relevance 0.10 Pain Relevance 0

To clarify the indirect participation of PGE2 on the expression of RANKL, OPG, and M-CSF in chondrocytes, we examined the effect of IL-1?

PGE2 Regulation (participation) of Gene_expression (expression) of OPG in chondrocytes

2) Confidence 0.04 Published 2009 Journal Mediators of Inflammation Section Body Doc Link PMC2829618 Disease Relevance 0 Pain Relevance 0

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