INT298584

Context Info Confidence 0.22 First Reported 2009 Last Reported 2009 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 3 Disease Relevance 0.70 Pain Relevance 0.40

signal transduction (IL1B, TNFRSF11B) extracellular region (IL1B, TNFRSF11B) cytosol (IL1B) extracellular space (IL1B) aging (IL1B) proteinaceous extracellular matrix (TNFRSF11B)

Anatomy Link Frequency chondrocytes 3 osteoblasts 1 IL1B (Homo sapiens) TNFRSF11B (Homo sapiens)

Pain Link Frequency Relevance Heat Snapping jaw 24 86.00 Pain 6 79.04 Inflammation 18 74.76 cytokine 18 48.64 Osteoarthritis 3 42.80 metalloproteinase 3 5.00 Hyperalgesia 3 5.00

Disease Link Frequency Relevance Heat Arthropathy 12 87.36 Temporomandibular Joint Syndrome 24 86.00 Pain 6 79.04 INFLAMMATION 18 74.76 Osteoporosis 3 63.12 Osteoarthritis 3 42.80 Chondrosarcoma 3 11.12 Targeted Disruption 3 5.68 Hypercalcemia 6 5.00 Hyperalgesia 3 5.00

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Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Therefore, these previous studies suggest that the effect of IL-1 on RANKL expression is the same in osteoblasts and chondrocytes; whereas the effect of IL-1 on OPG and M-CSF expression differs according to cell type and IL-1 subtype.

IL-1 Regulation (effect) of Gene_expression (expression) of OPG in chondrocytes

1) Confidence 0.22 Published 2009 Journal Mediators of Inflammation Section Body Doc Link PMC2829618 Disease Relevance 0 Pain Relevance 0

Conflicting results have been reported regarding the effect of IL-1 on OPG expression, mostly likely because different cells were used in each study [1, 2, 5].

IL-1 Regulation (effect) of Gene_expression (expression) of OPG

2) Confidence 0.13 Published 2009 Journal Mediators of Inflammation Section Body Doc Link PMC2829618 Disease Relevance 0.70 Pain Relevance 0.40

Therefore, these previous studies suggest that the effect of IL-1 on RANKL expression is the same in osteoblasts and chondrocytes; whereas the effect of IL-1 on OPG and M-CSF expression differs according to cell type and IL-1 subtype.

IL-1 Regulation (effect) of in osteoblasts Gene_expression (expression) of OPG in chondrocytes

3) Confidence 0.08 Published 2009 Journal Mediators of Inflammation Section Body Doc Link PMC2829618 Disease Relevance 0 Pain Relevance 0

General Comments

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