INT298588

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Context Info
Confidence 0.35
First Reported 2009
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 3
Disease Relevance 0.59
Pain Relevance 0.36

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (IL1B, CSF1) extracellular region (IL1B, CSF1) cell differentiation (CSF1)
aging (IL1B) cell-cell signaling (IL1B) cytosol (IL1B)
Anatomy Link Frequency
chondrocytes 5
osteoblasts 1
IL1B (Homo sapiens)
CSF1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 18 79.40 Quite High
Snapping jaw 24 76.88 Quite High
Pain 6 69.92 Quite High
cytokine 18 51.00 Quite High
Osteoarthritis 3 33.68 Quite Low
metalloproteinase 3 5.00 Very Low Very Low Very Low
Hyperalgesia 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
INFLAMMATION 18 79.40 Quite High
Arthropathy 12 78.24 Quite High
Temporomandibular Joint Syndrome 24 76.88 Quite High
Pain 6 69.92 Quite High
Osteoporosis 3 67.76 Quite High
Osteoarthritis 3 33.68 Quite Low
Targeted Disruption 3 5.68 Low Low
Hypercalcemia 6 5.00 Very Low Very Low Very Low
Hyperalgesia 3 5.00 Very Low Very Low Very Low
Milium 3 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Therefore, these previous studies suggest that the effect of IL-1 on RANKL expression is the same in osteoblasts and chondrocytes; whereas the effect of IL-1 on OPG and M-CSF expression differs according to cell type and IL-1 subtype.
IL-1 Regulation (effect) of Gene_expression (expression) of M-CSF in chondrocytes
1) Confidence 0.35 Published 2009 Journal Mediators of Inflammation Section Body Doc Link PMC2829618 Disease Relevance 0 Pain Relevance 0
stimulation prompted M-CSF production [2]; whereas the effect of IL-1 on M-CSF expression in chondrocytes is unclear.
IL-1 Regulation (effect) of Gene_expression (expression) of M-CSF in chondrocytes
2) Confidence 0.15 Published 2009 Journal Mediators of Inflammation Section Body Doc Link PMC2829618 Disease Relevance 0.59 Pain Relevance 0.36
Therefore, these previous studies suggest that the effect of IL-1 on RANKL expression is the same in osteoblasts and chondrocytes; whereas the effect of IL-1 on OPG and M-CSF expression differs according to cell type and IL-1 subtype.
IL-1 Regulation (effect) of in osteoblasts Gene_expression (expression) of M-CSF in chondrocytes
3) Confidence 0.12 Published 2009 Journal Mediators of Inflammation Section Body Doc Link PMC2829618 Disease Relevance 0 Pain Relevance 0

General Comments

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