INT298634

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Context Info
Confidence 0.04
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 1.41
Pain Relevance 0.08

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (STAT3) aging (IL6) DNA binding (STAT3)
cytoplasm (STAT3) signal transducer activity (STAT3) cell proliferation (STAT3)
IL6 (Homo sapiens)
STAT3 (Homo sapiens)
Pain Link Frequency Relevance Heat
agonist 86 82.88 Quite High
Inflammation 48 77.60 Quite High
dexamethasone 6 19.36 Low Low
ischemia 8 5.00 Very Low Very Low Very Low
metalloproteinase 6 5.00 Very Low Very Low Very Low
cytokine 4 5.00 Very Low Very Low Very Low
Inflammatory response 4 5.00 Very Low Very Low Very Low
corticosteroid 2 5.00 Very Low Very Low Very Low
Central nervous system 2 5.00 Very Low Very Low Very Low
cva 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Multiple Myeloma 106 97.32 Very High Very High Very High
Hematologic Neoplasms 78 93.40 High High
Apoptosis 54 89.52 High High
Repression 8 87.28 High High
Cancer 294 85.00 Quite High
INFLAMMATION 54 77.60 Quite High
Wound Healing 4 73.84 Quite High
Breast Cancer 12 62.52 Quite High
Metastasis 28 60.24 Quite High
Disease 26 59.32 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Two bona fide IL-6 type II-response elements for Stat3 binding are located upstream of the miR-21 genes of various vertebrate species [257].
IL-6 Binding (binding) of Stat3
1) Confidence 0.04 Published 2010 Journal PPAR Research Section Body Doc Link PMC2829627 Disease Relevance 0.89 Pain Relevance 0
to Stat3 forming a complex such that Stat3 is no longer capable of binding to the type II IL-6 response element on promoters of Stat3 target genes, troglitazone induces the redistribution of the corepressor NCoR/SMRT from PPAR?
type II IL-6 Binding (binding) of Stat3
2) Confidence 0.04 Published 2010 Journal PPAR Research Section Body Doc Link PMC2829627 Disease Relevance 0.52 Pain Relevance 0.08

General Comments

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