INT298640

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Context Info
Confidence 0.01
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.73
Pain Relevance 0.03

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (IL6R, STAT3) nucleoplasm (STAT3) DNA binding (STAT3)
enzyme binding (IL6R) cytoplasm (STAT3) signal transducer activity (STAT3)
IL6R (Homo sapiens)
STAT3 (Homo sapiens)
Pain Link Frequency Relevance Heat
dexamethasone 3 55.04 Quite High
agonist 43 50.00 Quite Low
Inflammation 24 5.00 Very Low Very Low Very Low
ischemia 4 5.00 Very Low Very Low Very Low
metalloproteinase 3 5.00 Very Low Very Low Very Low
cytokine 2 5.00 Very Low Very Low Very Low
Inflammatory response 2 5.00 Very Low Very Low Very Low
corticosteroid 1 5.00 Very Low Very Low Very Low
Central nervous system 1 5.00 Very Low Very Low Very Low
cva 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Multiple Myeloma 53 98.76 Very High Very High Very High
Hematologic Neoplasms 39 71.12 Quite High
Apoptosis 27 61.84 Quite High
Cancer 147 47.88 Quite Low
Solid Tumor 8 41.36 Quite Low
Metastasis 14 30.92 Quite Low
Myeloid Leukemia 5 16.32 Low Low
INFLAMMATION 27 5.00 Very Low Very Low Very Low
Lymphatic System Cancer 15 5.00 Very Low Very Low Very Low
Disease 13 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Bortezomib also triggered a dose-dependent inhibition of VEGF and IL-6 production by and secretion from MMECs and abrogated IL-6 triggered signaling cascades via caspase-dependent downregulation of gp130 in MM [218]; gp130 is the signaling component of the high affinity IL-6R complex that activates Stat3.
IL-6R Positive_regulation (activates) of Stat3 associated with multiple myeloma
1) Confidence 0.01 Published 2010 Journal PPAR Research Section Body Doc Link PMC2829627 Disease Relevance 0.73 Pain Relevance 0.03

General Comments

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