INT298661

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Context Info
Confidence 0.04
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 5
Total Number 5
Disease Relevance 3.42
Pain Relevance 0.26

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

lipid metabolic process (GDE1) cytoplasm (GDE1)
Anatomy Link Frequency
bone marrow 1
GDE1 (Homo sapiens)
Pain Link Frequency Relevance Heat
agonist 129 88.64 High High
Inflammation 72 87.16 High High
cytokine 6 57.28 Quite High
antagonist 7 36.24 Quite Low
metalloproteinase 10 5.44 Low Low
ischemia 12 5.00 Very Low Very Low Very Low
dexamethasone 9 5.00 Very Low Very Low Very Low
aspirin 7 5.00 Very Low Very Low Very Low
Inflammatory response 6 5.00 Very Low Very Low Very Low
cINOD 5 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Multiple Myeloma 159 99.14 Very High Very High Very High
Repression 13 97.12 Very High Very High Very High
Chronic Lymphoid Leukemia 21 97.00 Very High Very High Very High
Cancer 454 95.52 Very High Very High Very High
Hematologic Neoplasms 117 93.28 High High
INFLAMMATION 82 87.16 High High
Malignant Neoplastic Disease 34 83.16 Quite High
Epstein-barr Virus 3 82.12 Quite High
Gastrointestinal Neoplasms 2 81.52 Quite High
B-cell Lymphoma 3 74.64 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Recently, Roccaro and colleagues [249] identified a multiple myeloma-specific miRNA signature characterized by downexpression of miR-15a and miR-16 and overexpression of miR-222, miR-221, miR-382, miR-181a, and miR-181b in bone marrow-derived CD138+ MM cells.
Gene_expression (downexpression) of miR-16 in bone marrow associated with multiple myeloma
1) Confidence 0.04 Published 2010 Journal PPAR Research Section Body Doc Link PMC2829627 Disease Relevance 1.17 Pain Relevance 0.12
Deletion or downregulated expression of miR-15a and miR-16 on chromosome 13 is also found in MM cells [249]; deletion of chromosome 13 predicts significantly reduced survival in patients with MM [250].
Gene_expression (expression) of miR-16 associated with multiple myeloma
2) Confidence 0.04 Published 2010 Journal PPAR Research Section Body Doc Link PMC2829627 Disease Relevance 1.01 Pain Relevance 0
Amplification and sequencing of the glycerophosphodiester phosphodiesterase (glpQ) gene
Gene_expression (Amplification) of glycerophosphodiester phosphodiesterase
3) Confidence 0.04 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2991353 Disease Relevance 0 Pain Relevance 0
However, both miR-15a and miR-16 are deleted on chromosome 13 associated with MM [249] thereby preventing normal repression of cell proliferation during cancer progression.
Gene_expression (deleted) of miR-16 associated with cancer, repression and multiple myeloma
4) Confidence 0.04 Published 2010 Journal PPAR Research Section Body Doc Link PMC2829627 Disease Relevance 1.09 Pain Relevance 0.13
-catenin control of the intensity and spatial pattern of Nodal responsiveness is thought to be regulated by miR-15 and miR-16 expression [93].
Gene_expression (expression) of miR-16
5) Confidence 0.03 Published 2010 Journal Mol Cancer Section Body Doc Link PMC2955614 Disease Relevance 0.15 Pain Relevance 0

General Comments

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