INT298673

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Context Info
Confidence 0.49
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 5
Disease Relevance 2.33
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (HOXA5) DNA binding (HOXA5)
Anatomy Link Frequency
stem cell 2
precursor cells 1
HOXA5 (Homo sapiens)
Pain Link Frequency Relevance Heat
agonist 43 50.00 Quite Low
Inflammation 36 5.00 Very Low Very Low Very Low
aspirin 12 5.00 Very Low Very Low Very Low
cytokine 6 5.00 Very Low Very Low Very Low
antagonist 5 5.00 Very Low Very Low Very Low
Angina 4 5.00 Very Low Very Low Very Low
ischemia 4 5.00 Very Low Very Low Very Low
dexamethasone 3 5.00 Very Low Very Low Very Low
metalloproteinase 3 5.00 Very Low Very Low Very Low
Inflammatory response 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Coronary Artery Disease 264 96.40 Very High Very High Very High
Cancer 155 93.24 High High
Wound Healing 2 92.96 High High
Hematologic Neoplasms 39 82.64 Quite High
Breast Cancer 6 81.64 Quite High
Metastasis 14 79.36 Quite High
Disease 29 78.44 Quite High
Apoptosis 47 77.88 Quite High
Multiple Myeloma 53 75.84 Quite High
Glioblastoma 1 41.24 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Significantly, all but 1 of the measurable HOX genes, essential for stem cell self renewal and pluripotency were expressed at significantly higher levels in CD34+ cells with HOXA5 and HOXA9 being most strongly overexpressed (Table 4).


Gene_expression (overexpressed) of HOXA5 in stem cell
1) Confidence 0.49 Published 2010 Journal BMC Genomics Section Body Doc Link PMC2901320 Disease Relevance 0.57 Pain Relevance 0
Significantly, all but 1 of the measurable HOX genes, essential for stem cell self renewal and pluripotency were expressed at significantly higher levels in CD34+ cells with HOXA5 and HOXA9 being most strongly overexpressed (Table 4).


Gene_expression (expressed) of HOXA5 in stem cell
2) Confidence 0.49 Published 2010 Journal BMC Genomics Section Body Doc Link PMC2901320 Disease Relevance 0.57 Pain Relevance 0
Indeed we identified a high expression of HOXA5 transcripts in CD34+ precursor cells, which could therefore explain the expression of a subset of the KRAB factors.
Gene_expression (expression) of HOXA5 in precursor cells
3) Confidence 0.38 Published 2010 Journal BMC Genomics Section Body Doc Link PMC2901320 Disease Relevance 0 Pain Relevance 0
Next, we compared the list of KRAB factor genes to curated genesets in the Molecular Signatures Database (MSigDB) [13], showing substantial overlap with genes that can be induced by the homeodomain containing protein HOXA5 [14].
Gene_expression (containing) of HOXA5
4) Confidence 0.37 Published 2010 Journal BMC Genomics Section Body Doc Link PMC2901320 Disease Relevance 0.44 Pain Relevance 0
Furthermore, miR-130a functions in angiogenesis by inhibiting expression of two antiangiogenic homeobox transcription factors, HOXA5 and GAX [267].
Gene_expression (expression) of HOXA5
5) Confidence 0.22 Published 2010 Journal PPAR Research Section Body Doc Link PMC2829627 Disease Relevance 0.76 Pain Relevance 0

General Comments

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