INT298687

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Context Info
Confidence 0.50
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 2.09
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (OPA1, PARL) peptidase activity (PARL) nucleus (PARL)
mitochondrion organization (OPA1) GTPase activity (OPA1)
Anatomy Link Frequency
neuron 2
OPA1 (Homo sapiens)
PARL (Homo sapiens)
Pain Link Frequency Relevance Heat
Multiple sclerosis 2 5.00 Very Low Very Low Very Low
Neuritis 2 5.00 Very Low Very Low Very Low
alcohol 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Optic Atrophy 2 100.00 Very High Very High Very High
Nerve Degeneration 2 98.00 Very High Very High Very High
Myopia 82 97.68 Very High Very High Very High
Parkinson's Disease 4 92.64 High High
Stress 10 82.60 Quite High
Genetic Predisposition To Disease 2 81.28 Quite High
Leber Hereditary Optic Atrophy 12 14.56 Low Low
Disease 6 5.00 Very Low Very Low Very Low
Age-related Macular Degeneration 4 5.00 Very Low Very Low Very Low
Hyperopia 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Both MFN1 and PSARL encode mitochondrial membrane proteins that interact with Optic Atrophy 1 (OPA1), a mitochondrial protein known to cause retinal neuron degeneration when mutated [15,38].
Optic Atrophy 1 Binding (interact) of PSARL in neuron associated with optic atrophy and nerve degeneration
1) Confidence 0.50 Published 2010 Journal Molecular Vision Section Body Doc Link PMC2830021 Disease Relevance 1.04 Pain Relevance 0
Both MFN1 and PSARL encode mitochondrial membrane proteins that interact with Optic Atrophy 1 (OPA1), a mitochondrial protein known to cause retinal neuron degeneration when mutated [15,38].
OPA1 Binding (interact) of PSARL in neuron associated with optic atrophy and nerve degeneration
2) Confidence 0.38 Published 2010 Journal Molecular Vision Section Body Doc Link PMC2830021 Disease Relevance 1.05 Pain Relevance 0

General Comments

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