INT298782

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Context Info
Confidence 0.42
First Reported 2009
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 0.62
Pain Relevance 0.15

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

lipid binding (PPARA) nucleoplasm (PPARA) small molecule metabolic process (PPARA)
nucleus (PPARA) DNA binding (PPARA) lipid metabolic process (PPARA)
Anatomy Link Frequency
adipocyte 2
PPARA (Homo sapiens)
TUSC5 (Homo sapiens)
Pain Link Frequency Relevance Heat
agonist 48 99.84 Very High Very High Very High
Potency 4 5.00 Very Low Very Low Very Low
lidocaine 2 5.00 Very Low Very Low Very Low
Central nervous system 2 5.00 Very Low Very Low Very Low
anesthesia 2 5.00 Very Low Very Low Very Low
dexamethasone 2 5.00 Very Low Very Low Very Low
Peripheral nervous system 2 5.00 Very Low Very Low Very Low
Immobilon 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Obesity 276 98.32 Very High Very High Very High
Diabetes Mellitus 20 73.88 Quite High
Cancer 10 50.00 Quite Low
Disease 2 31.48 Quite Low
Liver Cancer 6 5.00 Very Low Very Low Very Low
Retinoblastoma 2 5.00 Very Low Very Low Very Low
Insulin Resistance 2 5.00 Very Low Very Low Very Low
Repression 2 5.00 Very Low Very Low Very Low
Targeted Disruption 2 5.00 Very Low Very Low Very Low
Lung Cancer 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The basis for the unique tissue specificity of Tusc5 expression remains unexplored, but the robust activation of Tusc5 gene expression by PPAR?
PPAR Positive_regulation (activation) of Gene_expression (expression) of Tusc5 gene
1) Confidence 0.42 Published 2009 Journal PPAR Research Section Body Doc Link PMC2830574 Disease Relevance 0.53 Pain Relevance 0.05
A non-adipocyte cell type that strongly expresses Tusc5 is the peripheral afferent neuron, so it will be interesting to determine if Tusc5 expression can be increased by PPAR?
PPAR Positive_regulation (increased) of Gene_expression (expression) of Tusc5 in adipocyte
2) Confidence 0.37 Published 2009 Journal PPAR Research Section Body Doc Link PMC2830574 Disease Relevance 0.09 Pain Relevance 0.10

General Comments

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