INT298785

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Context Info
Confidence 0.29
First Reported 2009
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 1.58
Pain Relevance 0.23

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

small molecule metabolic process (PPARA, ACOX1) lipid metabolic process (PPARA, ACOX1) nucleoplasm (PPARA)
mitochondrion (ACOX1) peroxisome (ACOX1) DNA binding (PPARA)
PPARA (Homo sapiens)
ACOX1 (Homo sapiens)
Pain Link Frequency Relevance Heat
agonist 78 99.04 Very High Very High Very High
Bile 9 39.24 Quite Low
Inflammation 14 5.00 Very Low Very Low Very Low
Potency 4 5.00 Very Low Very Low Very Low
Central nervous system 2 5.00 Very Low Very Low Very Low
anesthesia 2 5.00 Very Low Very Low Very Low
dexamethasone 2 5.00 Very Low Very Low Very Low
Peripheral nervous system 2 5.00 Very Low Very Low Very Low
Inflammatory response 2 5.00 Very Low Very Low Very Low
Endocannabinoid 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Hepatocellular Cancer 2 94.40 High High
Liver Cancer 7 89.84 High High
Obesity 290 82.92 Quite High
Cancer 11 50.00 Quite Low
Diabetes Mellitus 21 5.00 Very Low Very Low Very Low
INFLAMMATION 16 5.00 Very Low Very Low Very Low
Disorder Of Lipid Metabolism 14 5.00 Very Low Very Low Very Low
Nash(non-alcoholic Steatohepatitis) 3 5.00 Very Low Very Low Very Low
Retinoblastoma 2 5.00 Very Low Very Low Very Low
Fatty Liver 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
ACOX1 and CPT1b were induced by PPAR?
PPAR Positive_regulation (induced) of ACOX1
1) Confidence 0.29 Published 2009 Journal PPAR Research Section Body Doc Link PMC2830574 Disease Relevance 0.69 Pain Relevance 0.10
agonism, but interestingly ACOX1 was also significantly increased by PPAR?
PPAR Positive_regulation (increased) of ACOX1
2) Confidence 0.25 Published 2009 Journal PPAR Research Section Body Doc Link PMC2830574 Disease Relevance 0.71 Pain Relevance 0.10
Initially, it was believed that the differential response was due to the lack activation of Acox1 and other peroxisomal genes by PPAR?
PPAR Positive_regulation (activation) of Acox1
3) Confidence 0.23 Published 2010 Journal PPAR Research Section Body Doc Link PMC2948931 Disease Relevance 0.18 Pain Relevance 0.04

General Comments

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