INT29879

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Context Info
Confidence 0.70
First Reported 1982
Last Reported 2009
Negated 0
Speculated 1
Reported most in Abstract
Documents 9
Total Number 10
Disease Relevance 3.13
Pain Relevance 2.62

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (GGH) extracellular space (GGH) extracellular region (GGH)
lysosome (GGH)
Anatomy Link Frequency
plasma 3
GGH (Homo sapiens)
Pain Link Frequency Relevance Heat
Sumatriptan 10 100.00 Very High Very High Very High
narcan 18 98.88 Very High Very High Very High
headache 2 98.72 Very High Very High Very High
antidepressant 6 94.92 High High
gABA 1 93.68 High High
agonist 2 93.32 High High
GABAergic 2 90.68 High High
Pain 11 90.60 High High
Opioid 4 89.76 High High
Endogenous opioid 2 72.96 Quite High
Disease Link Frequency Relevance Heat
Herpes Simplex Virus Infection 162 100.00 Very High Very High Very High
Mental Disorders 20 99.60 Very High Very High Very High
Lipodystrophy 1 98.94 Very High Very High Very High
Sexually Transmitted Diseases 4 98.48 Very High Very High Very High
Recurrence 10 97.12 Very High Very High Very High
Disease 33 92.00 High High
Pain 9 90.60 High High
Aging 2 88.72 High High
Communicable Diseases 4 78.60 Quite High
Chronic Disease 11 77.96 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
GH levels increased significantly above basal value either after baclofen and naloxone plus baclofen without any significant difference between GH responses during the two tests.
Positive_regulation (increased) of GH associated with narcan
1) Confidence 0.70 Published 1983 Journal J. Endocrinol. Invest. Section Abstract Doc Link 6319478 Disease Relevance 0 Pain Relevance 0.43
From the data available, the incidence of clinically manifest GH can be estimated to be 423,000 cases and the number of recurrent cases at about 698,000 patients in 1996.
Positive_regulation (estimated) of GH associated with herpes simplex virus infection
2) Confidence 0.50 Published 2001 Journal BMC Infect Dis Section Body Doc Link PMC35281 Disease Relevance 0.94 Pain Relevance 0
In addition, it must be underlined that GH constitutes a risk factor for the spread of other sexually transmitted diseases (e.g. human immunodeficency virus), which can be interpreted as a negative consequence of GH.
Positive_regulation (consequence) of GH associated with sexually transmitted diseases and herpes simplex virus infection
3) Confidence 0.50 Published 2001 Journal BMC Infect Dis Section Body Doc Link PMC35281 Disease Relevance 1.22 Pain Relevance 0
Sumatriptan-induced plasma GH rise was recorded during the next 2 hours.
Positive_regulation (Sumatriptan-induced) of GH in plasma associated with sumatriptan
4) Confidence 0.47 Published 1995 Journal J. Neural Transm. Gen. Sect. Section Abstract Doc Link 8695049 Disease Relevance 0.09 Pain Relevance 0.47
Sumatriptan induced a striking increase in plasma GH levels in the younger group, whereas it slightly increased GH secretion in the older group (f = 9.59, p < 0.02).
Positive_regulation (increase) of GH in plasma associated with sumatriptan
5) Confidence 0.44 Published 1995 Journal J. Neural Transm. Gen. Sect. Section Abstract Doc Link 8695049 Disease Relevance 0.08 Pain Relevance 0.48
Lipoatrophy in GH deficient patients treated with a long-acting pegylated GH.
Positive_regulation (pegylated) of GH associated with headache
6) Confidence 0.41 Published 2009 Journal Eur. J. Endocrinol. Section Title Doc Link 19654233 Disease Relevance 0.10 Pain Relevance 0.20
Plasma ACTH, cortisol, PRL and GH concentrations were significantly increased by physical exercise.
Positive_regulation (increased) of GH in Plasma
7) Confidence 0.23 Published 1988 Journal Acta Endocrinol. Section Abstract Doc Link 2847472 Disease Relevance 0 Pain Relevance 0.32
These data show that oxytocin is capable of inhibiting the rise in ACTH and cortisol, but not in GH and PRL induced by physical exercise.
Positive_regulation (induced) of GH
8) Confidence 0.23 Published 1988 Journal Acta Endocrinol. Section Abstract Doc Link 2847472 Disease Relevance 0 Pain Relevance 0.39
It is likely that such studies will enrich our understanding of how these agents work, of the difference between agents which have been classed together on the basis of preclinical studies (e.g., DMI, which appears to increase PRL and GH, and NT which appears not to) and provided additional evidence to test current hypotheses about the biological basis of their antidepressant action.
Spec (appears) Positive_regulation (increase) of GH associated with antidepressant
9) Confidence 0.23 Published 1982 Journal Adv. Biochem. Psychopharmacol. Section Abstract Doc Link 6124090 Disease Relevance 0 Pain Relevance 0.24
Similarly, frequent activities increased the quality of life in the PF, GH, VT, and MH dimensions (p-value < 0.05).
Positive_regulation (increased) of GH associated with mental disorders
10) Confidence 0.21 Published 2008 Journal BMC Public Health Section Body Doc Link PMC2527564 Disease Relevance 0.70 Pain Relevance 0.09

General Comments

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