INT298807

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Context Info
Confidence 0.69
First Reported 2009
Last Reported 2009
Negated 2
Speculated 0
Reported most in Body
Documents 1
Total Number 13
Disease Relevance 6.08
Pain Relevance 0.64

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
adipocytes 4
liver 2
hepatocyte 2
TUSC5 (Homo sapiens)
Pain Link Frequency Relevance Heat
agonist 312 99.20 Very High Very High Very High
Potency 26 96.56 Very High Very High Very High
anesthesia 13 20.56 Low Low
lidocaine 13 20.12 Low Low
Central nervous system 13 5.00 Very Low Very Low Very Low
dexamethasone 13 5.00 Very Low Very Low Very Low
Peripheral nervous system 13 5.00 Very Low Very Low Very Low
Immobilon 13 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Obesity 1794 100.00 Very High Very High Very High
Diabetes Mellitus 130 98.90 Very High Very High Very High
Liver Cancer 39 95.76 Very High Very High Very High
Targeted Disruption 13 94.48 High High
Disease 13 79.28 Quite High
Cancer 65 50.00 Quite Low
Insulin Resistance 13 47.40 Quite Low
Retinoblastoma 13 21.20 Low Low
Repression 13 5.00 Very Low Very Low Very Low
Lung Cancer 13 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The lack of effect of PIO in triggering WAT Tusc5 expression in our human cohorts (in contrast to the robust increase in murine adipocytes) might point to potential species-specific differences in the Tusc5-PPAR?
Positive_regulation (triggering) of Gene_expression (expression) of WAT Tusc5 in adipocytes associated with obesity
1) Confidence 0.69 Published 2009 Journal PPAR Research Section Body Doc Link PMC2830574 Disease Relevance 0.73 Pain Relevance 0.03
However, in subjects treated for the same period of time but using rosiglitazone, there was a trend for increased Tusc5 mRNA expression: 3132 ± 351 versus 4286 ± 433 (P = .07).

3.2.

Positive_regulation (increased) of Gene_expression (expression) of Tusc5 mRNA
2) Confidence 0.69 Published 2009 Journal PPAR Research Section Body Doc Link PMC2830574 Disease Relevance 0.59 Pain Relevance 0.04
Microarray gene expression results from a separate cohort of type 2 diabetics treated with pioglitizone for 12 weeks also showed no increased Tusc5 transcript levels in the WAT when comparing pre- versus posttreatment matched samples (in arbitrary fluorescence signal units): 3084 ± 564 versus 3017 ± 601 in pre- versus posttreatment, respectively (P > .1).
Neg (no) Positive_regulation (increased) of Neg (no) Gene_expression (levels) of Tusc5 associated with diabetes mellitus and obesity
3) Confidence 0.50 Published 2009 Journal PPAR Research Section Body Doc Link PMC2830574 Disease Relevance 0.63 Pain Relevance 0.05
2 on hepatic expression of Tusc5, archived samples were used from a previously published experiment in which C57BL/6 mice were i.v. treated with adenovirus preparations containing either murine PPAR?
Positive_regulation (on) of Gene_expression (expression) of Tusc5
4) Confidence 0.50 Published 2009 Journal PPAR Research Section Body Doc Link PMC2830574 Disease Relevance 0.27 Pain Relevance 0
We reasoned that Tusc5 expression, like that of the classic PPAR?
Positive_regulation (reasoned) of Gene_expression (expression) of Tusc5
5) Confidence 0.50 Published 2009 Journal PPAR Research Section Body Doc Link PMC2830574 Disease Relevance 0.39 Pain Relevance 0
The basis for the unique tissue specificity of Tusc5 expression remains unexplored, but the robust activation of Tusc5 gene expression by PPAR?
Positive_regulation (activation) of Gene_expression (expression) of Tusc5 gene
6) Confidence 0.50 Published 2009 Journal PPAR Research Section Body Doc Link PMC2830574 Disease Relevance 0.53 Pain Relevance 0.05
However, liver Tusc5 mRNA changes following hepatic PPAR?
Positive_regulation (liver) of Gene_expression (liver) of Tusc5 mRNA in liver
7) Confidence 0.50 Published 2009 Journal PPAR Research Section Body Doc Link PMC2830574 Disease Relevance 0.37 Pain Relevance 0.03
Second, in another set of studies addressing whether Tusc5 expression can be induced in non-adipocytes overexpressing PPAR?
Positive_regulation (induced) of Gene_expression (expression) of Tusc5 in adipocytes associated with obesity
8) Confidence 0.46 Published 2009 Journal PPAR Research Section Body Doc Link PMC2830574 Disease Relevance 0.42 Pain Relevance 0
The activation of Tusc5 gene expression by both agents, and the fact that the magnitude of EC50 differences match the known potency of these molecules for binding and activating PPAR?
Positive_regulation (activation) of Gene_expression (expression) of Tusc5 gene associated with potency
9) Confidence 0.46 Published 2009 Journal PPAR Research Section Body Doc Link PMC2830574 Disease Relevance 0.12 Pain Relevance 0.21
This suggests that up-regulation of Tusc5 expression by these compounds is not due to off-target effects and is not agonist class specific.
Positive_regulation (regulation) of Gene_expression (expression) of Tusc5 associated with agonist
10) Confidence 0.46 Published 2009 Journal PPAR Research Section Body Doc Link PMC2830574 Disease Relevance 0.67 Pain Relevance 0.17
1 overexpression on expression of Tusc5, samples were used from a previously published study in which PPAR?
Positive_regulation (overexpression) of Gene_expression (expression) of Tusc5
11) Confidence 0.46 Published 2009 Journal PPAR Research Section Body Doc Link PMC2830574 Disease Relevance 0.33 Pain Relevance 0
There is little evidence for a major role for Tusc5 WAT expression differences in obesity development, and although we identified several missense mutations in the TUSC5 gene locus, none was associated with adiposity in a large human cohort.
Positive_regulation (role) of Gene_expression (expression) of Tusc5 WAT associated with obesity
12) Confidence 0.46 Published 2009 Journal PPAR Research Section Body Doc Link PMC2830574 Disease Relevance 0.77 Pain Relevance 0
Expression of Tusc5 could not be induced in the human hepatocyte cell line HepG2 even after maneuvers that increased PPAR activity and hence expression of assorted PPAR target genes (Table 2; also see [14]).
Neg (not) Positive_regulation (induced) of Gene_expression (Expression) of Tusc5 in hepatocyte
13) Confidence 0.46 Published 2009 Journal PPAR Research Section Body Doc Link PMC2830574 Disease Relevance 0.26 Pain Relevance 0.06

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