INT298812

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Context Info
Confidence 0.61
First Reported 2009
Last Reported 2009
Negated 0
Speculated 1
Reported most in Body
Documents 1
Total Number 5
Disease Relevance 2.97
Pain Relevance 0.23

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
afferent neurons 2
TUSC5 (Homo sapiens)
Pain Link Frequency Relevance Heat
agonist 120 96.80 Very High Very High Very High
Central nervous system 5 67.08 Quite High
Peripheral nervous system 5 57.08 Quite High
Potency 10 5.00 Very Low Very Low Very Low
lidocaine 5 5.00 Very Low Very Low Very Low
anesthesia 5 5.00 Very Low Very Low Very Low
dexamethasone 5 5.00 Very Low Very Low Very Low
Immobilon 5 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Obesity 690 100.00 Very High Very High Very High
Disease 5 94.20 High High
Repression 5 78.88 Quite High
Cancer 25 69.52 Quite High
Diabetes Mellitus 50 57.16 Quite High
Lung Cancer 5 29.88 Quite Low
Liver Cancer 15 5.00 Very Low Very Low Very Low
Retinoblastoma 5 5.00 Very Low Very Low Very Low
Insulin Resistance 5 5.00 Very Low Very Low Very Low
Targeted Disruption 5 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Finally, considering that samples were obtained only at a single late timepoint following pioglitazone treatment, it is possible that WAT Tusc5 expression was actively regulated during the more dynamic phase of early TZD treatment.
Spec (possible) Regulation (regulated) of Gene_expression (expression) of WAT Tusc5 associated with obesity
1) Confidence 0.61 Published 2009 Journal PPAR Research Section Body Doc Link PMC2830574 Disease Relevance 0.56 Pain Relevance 0
Tusc5 displays an interesting biology, in that it is robustly coexpressed in both adipocytes and peripheral afferent neurons, but its function has remained elusive and very little is known about the molecular regulation of Tusc5 gene expression.
Regulation (regulation) of Gene_expression (expression) of Tusc5 gene in afferent neurons associated with obesity
2) Confidence 0.27 Published 2009 Journal PPAR Research Section Body Doc Link PMC2830574 Disease Relevance 0.62 Pain Relevance 0.03
Therefore, these results are consistent with the hypothesis that Tusc5 expression, like other genes triggered during the adipogenesis program, is regulated through increased histone acetylation at PPAR?
Regulation (regulated) of Gene_expression (expression) of Tusc5
3) Confidence 0.27 Published 2009 Journal PPAR Research Section Body Doc Link PMC2830574 Disease Relevance 0.11 Pain Relevance 0.05
Up regulation of Tusc5 gene expression by a single concentration of the PPAR?
Regulation (regulation) of Gene_expression (expression) of Tusc5 gene
4) Confidence 0.27 Published 2009 Journal PPAR Research Section Body Doc Link PMC2830574 Disease Relevance 0.71 Pain Relevance 0.05
Identifying factors that influence Tusc5 gene expression and gaining a better understanding of associations between the TUSC5 gene sequence, expression patterns, and obesity will enable a deeper understanding of its physiological function.
Regulation (influence) of Gene_expression (expression) of Tusc5 gene associated with obesity
5) Confidence 0.27 Published 2009 Journal PPAR Research Section Body Doc Link PMC2830574 Disease Relevance 0.96 Pain Relevance 0.10

General Comments

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