INT298819

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Context Info
Confidence 0.37
First Reported 2009
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 4
Disease Relevance 2.41
Pain Relevance 0.27

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
adipocytes 2
TUSC5 (Homo sapiens)
Pain Link Frequency Relevance Heat
agonist 96 95.68 Very High Very High Very High
dexamethasone 4 34.08 Quite Low
Central nervous system 4 20.60 Low Low
Peripheral nervous system 4 10.60 Low Low
Potency 8 5.00 Very Low Very Low Very Low
lidocaine 4 5.00 Very Low Very Low Very Low
anesthesia 4 5.00 Very Low Very Low Very Low
Immobilon 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Obesity 552 98.48 Very High Very High Very High
Cancer 20 50.00 Quite Low
Retinoblastoma 4 37.52 Quite Low
Repression 4 32.40 Quite Low
Diabetes Mellitus 40 5.00 Very Low Very Low Very Low
Liver Cancer 12 5.00 Very Low Very Low Very Low
Insulin Resistance 4 5.00 Very Low Very Low Very Low
Targeted Disruption 4 5.00 Very Low Very Low Very Low
Lung Cancer 4 5.00 Very Low Very Low Very Low
Disease 4 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
-TUSC5 interactions, Tusc5 mRNA levels were compared in archived human WAT biopsy samples before and after treatment with the PPAR?
TUSC5 Binding (interactions) of associated with obesity
1) Confidence 0.37 Published 2009 Journal PPAR Research Section Body Doc Link PMC2830574 Disease Relevance 0.69 Pain Relevance 0.08
-TUSC5 interaction is highly-complex, temporally-regulated during adipogenesis, and involves tissue specific factors driving expression of the gene in adipocytes in response to experimental PPAR?
TUSC5 Binding (interaction) of in adipocytes associated with obesity
2) Confidence 0.35 Published 2009 Journal PPAR Research Section Body Doc Link PMC2830574 Disease Relevance 1.02 Pain Relevance 0
binding to the Tusc5 promoter was transient despite maintenance of histone acetylation at the DR1 sites throughout 3T3-L1 adipocyte maturation, suggesting that acetylation and hence concomitant transcription factor accessibility to these sites does not alone explain temporal changes in PPAR?
Tusc5 Binding (binding) of in adipocyte
3) Confidence 0.35 Published 2009 Journal PPAR Research Section Body Doc Link PMC2830574 Disease Relevance 0.20 Pain Relevance 0.03
directly binds one predicted TUSC5 DR1 site strongly (a ?
TUSC5 Binding (binds) of
4) Confidence 0.31 Published 2009 Journal PPAR Research Section Body Doc Link PMC2830574 Disease Relevance 0.50 Pain Relevance 0.16

General Comments

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