INT298822

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Context Info
Confidence 0.69
First Reported 2009
Last Reported 2009
Negated 1
Speculated 0
Reported most in Body
Documents 1
Total Number 8
Disease Relevance 5.45
Pain Relevance 0.51

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
adipose tissue 1
3T3-L1 1
TUSC5 (Homo sapiens)
Pain Link Frequency Relevance Heat
agonist 192 99.84 Very High Very High Very High
Potency 16 80.64 Quite High
lidocaine 8 5.00 Very Low Very Low Very Low
Central nervous system 8 5.00 Very Low Very Low Very Low
anesthesia 8 5.00 Very Low Very Low Very Low
dexamethasone 8 5.00 Very Low Very Low Very Low
Peripheral nervous system 8 5.00 Very Low Very Low Very Low
Immobilon 8 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Obesity 1104 100.00 Very High Very High Very High
Diabetes Mellitus 80 98.60 Very High Very High Very High
Liver Cancer 24 75.76 Quite High
Cancer 40 75.00 Quite High
Disease 8 38.80 Quite Low
Retinoblastoma 8 14.76 Low Low
Insulin Resistance 8 5.00 Very Low Very Low Very Low
Repression 8 5.00 Very Low Very Low Very Low
Targeted Disruption 8 5.00 Very Low Very Low Very Low
Lung Cancer 8 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Only one other study has addressed this question, using Zucker fatty rats that lack proper leptin signaling and therefore become extremely obese: Tusc5 mRNA and protein levels were very slightly increased in subcutaneous WAT, unchanged in mesenteric, and yet decreased substantially in epididymal WAT [4].
Positive_regulation (increased) of Tusc5 mRNA associated with obesity
1) Confidence 0.69 Published 2009 Journal PPAR Research Section Body Doc Link PMC2830574 Disease Relevance 0.96 Pain Relevance 0.04
In contrast, rosiglitazone tended to increase Tusc5 mRNA levels, but this was highly variable among the individuals tested.
Positive_regulation (increase) of Tusc5 mRNA
2) Confidence 0.69 Published 2009 Journal PPAR Research Section Body Doc Link PMC2830574 Disease Relevance 0.55 Pain Relevance 0.04
The lack of Tusc5 induction in HepG2 cells contrasted with a variety of PPAR target genes that were induced under conditions of PPAR activation (Table 1).
Positive_regulation (induction) of Tusc5
3) Confidence 0.69 Published 2009 Journal PPAR Research Section Body Doc Link PMC2830574 Disease Relevance 0.47 Pain Relevance 0.08
agonist pioglitazone [8], in which we did not detect an increase in WAT Tusc5 mRNA by quantitative PCR or protein despite increases in expression of other target genes (Figure 3).
Positive_regulation (increase) of WAT Tusc5 associated with obesity and agonist
4) Confidence 0.46 Published 2009 Journal PPAR Research Section Body Doc Link PMC2830574 Disease Relevance 0.52 Pain Relevance 0.05
Tusc5 protein level was also increased by agonist treatment (Supplementary Figure 1in supplementary material available online at doi: 10.1155/2009/86768).
Positive_regulation (increased) of Tusc5 protein associated with agonist
5) Confidence 0.46 Published 2009 Journal PPAR Research Section Body Doc Link PMC2830574 Disease Relevance 0.14 Pain Relevance 0.21
Induction of Tusc5 mRNA levels in 3T3-L1 adipocytes by troglitazone and GW1929 followed a dose-response consistent with these agents' binding affinities for PPAR?.
Positive_regulation (Induction) of Tusc5 mRNA in 3T3-L1 associated with obesity
6) Confidence 0.46 Published 2009 Journal PPAR Research Section Abstract Doc Link PMC2830574 Disease Relevance 1.23 Pain Relevance 0.04
Microarray adipose tissue expression data from a different human TZD study in type 2 diabetics confirmed the observation above that pioglitazone treatment does not increase Tusc5 mRNA levels.
Neg (not) Positive_regulation (increase) of Tusc5 mRNA in adipose tissue associated with diabetes mellitus and obesity
7) Confidence 0.46 Published 2009 Journal PPAR Research Section Body Doc Link PMC2830574 Disease Relevance 0.51 Pain Relevance 0.04
In conclusion, these experiments have established that the murine TUSC5 gene is a PPAR?
Positive_regulation (murine) of TUSC5 gene
8) Confidence 0.43 Published 2009 Journal PPAR Research Section Body Doc Link PMC2830574 Disease Relevance 1.07 Pain Relevance 0

General Comments

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