INT298847

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Context Info
Confidence 0.05
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.54
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (RILP) small molecule metabolic process (VAPA) endoplasmic reticulum (VAPA)
signal transducer activity (VAPA) signal transduction (VAPA) cell death (VAPA)
Anatomy Link Frequency
vesicles 1
VAPA (Homo sapiens)
RILP (Homo sapiens)
Pain Link Frequency Relevance Heat
imagery 5 5.00 Very Low Very Low Very Low
Pain 3 5.00 Very Low Very Low Very Low
Congenital analgesia 1 5.00 Very Low Very Low Very Low
Demyelination 1 5.00 Very Low Very Low Very Low
Nerve growth factor 1 5.00 Very Low Very Low Very Low
Peripheral nervous system 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Disease 76 94.08 High High
Motor Neuron Diseases 1 73.04 Quite High
Paraplegia 1 66.72 Quite High
Neurological Disease 2 57.04 Quite High
Choroideremia 1 54.48 Quite High
Intellectual Impairment 1 51.36 Quite High
Atrophic Muscular Disorders 1 47.76 Quite Low
Spinocerebellar Ataxia Type 2 1 43.60 Quite Low
Syndrome 2 37.68 Quite Low
Neurodegenerative Disease 4 9.04 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
High cholesterol levels on the cytosolic face of vesicles activate ORP1L leading to stable recruitment of dynein, whereas low cholesterol levels allow the extraction of motor proteins from Rab7–RILP complexes by VapA and B.
VapA Binding (complexes) of RILP in vesicles
1) Confidence 0.05 Published 2010 Journal Human Molecular Genetics Section Body Doc Link PMC2830827 Disease Relevance 0.54 Pain Relevance 0

General Comments

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