INT298876

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Context Info
Confidence 0.14
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.44
Pain Relevance 0.22

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (NTRK1) endosome (NTRK1) Golgi apparatus (RAB7A)
plasma membrane (NTRK1) GTPase activity (RAB7A) lysosome (RAB7A)
Anatomy Link Frequency
neurite 2
RAB7A (Homo sapiens)
NTRK1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Pain 3 73.12 Quite High
Nerve growth factor 1 59.28 Quite High
Congenital analgesia 1 55.92 Quite High
imagery 5 5.00 Very Low Very Low Very Low
Demyelination 1 5.00 Very Low Very Low Very Low
Peripheral nervous system 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Neurodegenerative Disease 4 84.80 Quite High
Pain 4 73.12 Quite High
Disease 76 55.68 Quite High
Syndrome 2 40.72 Quite Low
Neurological Disease 2 33.08 Quite Low
Spinocerebellar Ataxia Type 2 1 26.68 Quite Low
Atrophic Muscular Disorders 1 24.76 Low Low
Intellectual Impairment 1 22.56 Low Low
Choroideremia 1 20.80 Low Low
Paraplegia 1 14.88 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In cultured neurons, over-expression of dominant-negative Rab7 reduces the degradation of TrkA-containing signaling endosomes leading to increased trophic signaling and excessive neurite outgrowth (9).
Rab7 Positive_regulation (reduces) of Protein_catabolism (degradation) of TrkA-containing in neurite
1) Confidence 0.14 Published 2010 Journal Human Molecular Genetics Section Body Doc Link PMC2830827 Disease Relevance 0.44 Pain Relevance 0.22

General Comments

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